VEGFR2 Blockade Improves Renal Damage in an Experimental Model of Type 2 Diabetic Nephropathy

by Carolina Lavoz, Raul R. Rodrigues-Diez, Anita Plaza, Daniel Carpio, Jesús Egido, Marta Ruiz-Ortega, Sergio Mezzano
Published 2020-01-01

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

by Lucas Opazo-Ríos, Sebastián Mas, Gema Marín-Royo, Sergio Mezzano, Carmen Gómez-Guerrero, Juan Antonio Moreno, Jesús Egido
Published 2020-04-01

Tacrolimus Prevents TWEAK-Induced PLA2R Expression in Cultured Human Podocytes

by Leticia Cuarental, Lara Valiño-Rivas, Luis Mendonça, Moin Saleem, Sergio Mezzano, Ana Belen Sanz, Alberto Ortiz, Maria Dolores Sanchez-Niño
Published 2020-07-01

Anti-inflammatory, antioxidant and renoprotective effects of SOCS1 mimetic peptide in the BTBR ob/ob mouse model of type 2 diabetes

by Lucas Opazo-Ríos, Yenniffer Sanchez Matus, Raúl R Rodrigues-Díez, Daniel Carpio, Alejandra Droguett, Jesús Egido, Carmen Gomez-Guerrero, Sergio Mezzano
Published 2020-04-01

Role of connective tissue growth factor in vascular and renal damage associated with hypertension in rats. Interactions with angiotensin II

by Natalia de las Heras, Marta Ruiz-Ortega, Mónica Rupérez, David Sanz-Rosa, María Miana, Paloma Aragoncillo, Sergio Mezzano, Vicente Lahera, Jesús Egido, Victoria Cachofeiro
Published 2006-12-01

Targeting NF-κB by the Cell-Permeable NEMO-Binding Domain Peptide Improves Albuminuria and Renal Lesions in an Experimental Model of Type 2 Diabetic Nephropathy

by Lucas Opazo-Ríos, Anita Plaza, Yenniffer Sánchez Matus, Susana Bernal, Laura Lopez-Sanz, Luna Jimenez-Castilla, Daniel Carpio, Alejandra Droguett, Sergio Mezzano, Jesús Egido, Carmen Gomez-Guerrero
Published 2020-06-01

Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.

by Raúl Rodrigues Díez, Raquel Rodrigues-Díez, Carolina Lavoz, Sandra Rayego-Mateos, Esther Civantos, Juan Rodríguez-Vita, Sergio Mezzano, Alberto Ortiz, Jesús Egido, Marta Ruiz-Ortega, Marta Ruiz-Ortega
Published 2010-01-01

Gremlin Activates the Smad Pathway Linked to Epithelial Mesenchymal Transdifferentiation in Cultured Tubular Epithelial Cells

by Raquel Rodrigues-Diez, Raúl R. Rodrigues-Diez, Carolina Lavoz, Gisselle Carvajal, Alejandra Droguett, Ana B. Garcia-Redondo, Isabel Rodriguez, Alberto Ortiz, Jesús Egido, Sergio Mezzano, Marta Ruiz-Ortega
Published 2014-01-01

Angiotensin II contributes to renal fibrosis independently of Notch pathway activation.

by Carolina Lavoz, Raquel Rodrigues-Diez, Alberto Benito-Martin, Sandra Rayego-Mateos, Raúl R Rodrigues-Diez, Matilde Alique, Alberto Ortiz, Sergio Mezzano, Jesús Egido, Marta Ruiz-Ortega, Marta Ruiz-Ortega
Published 2012-01-01

Tubular overexpression of gremlin induces renal damage susceptibility in mice.

by Alejandra Droguett, Paola Krall, M Eugenia Burgos, Graciela Valderrama, Daniel Carpio, Leopoldo Ardiles, Raquel Rodriguez-Diez, Bredford Kerr, Katherina Walz, Marta Ruiz-Ortega, Marta Ruiz-Ortega, Jesus Egido, Sergio Mezzano
Published 2014-01-01

Could the Notch signaling pathway be a potential therapeutic option in renal diseases?

by Laura Marquez-Exposito, Elena Cantero-Navarro, Carolina Lavoz, Marta Fierro-Fernández, Jonay Poveda, Sandra Rayego-Mateos, Raúl R. Rodrigues-Diez, José Luis Morgado-Pascual, Macarena Orejudo, Sergio Mezzano, Marta Ruiz-Ortega
Published 2018-09-01

Análisis de la vía Notch como una posible diana terapéutica en la patología renal

by Laura Marquez-Exposito, Elena Cantero-Navarro, Carolina Lavoz, Marta Fierro-Fernández, Jonay Poveda, Sandra Rayego-Mateos, Raúl R. Rodrigues-Diez, José Luis Morgado-Pascual, Macarena Orejudo, Sergio Mezzano, Marta Ruiz-Ortega
Published 2018-09-01

Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation.

by Vanesa Esteban, Silvia Heringer-Walther, Anja Sterner-Kock, Ron de Bruin, Sandra van den Engel, Yong Wang, Sergio Mezzano, Jesus Egido, Heinz-Peter Schultheiss, Marta Ruiz-Ortega, Marta Ruiz-Ortega, Thomas Walther
Published 2009-01-01

Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy

by Sandra Rayego-Mateos, José Luis Morgado-Pascual, Lucas Opazo-Ríos, Melania Guerrero-Hue, Cristina García-Caballero, Cristina Vázquez-Carballo, Sebastián Mas, Ana Belén Sanz, Carmen Herencia, Sergio Mezzano, Carmen Gómez-Guerrero, Juan Antonio Moreno, Jesús Egido
Published 2020-05-01

Could IL-17A Be a Novel Therapeutic Target in Diabetic Nephropathy?

by Carolina Lavoz, Sandra Rayego-Mateos, Macarena Orejudo, Lucas Opazo-Ríos, Vanessa Marchant, Laura Marquez-Exposito, Antonio Tejera-Muñoz, Juan F. Navarro-González, Alejandra Droguett, Alberto Ortiz, Jesús Egido, Sergio Mezzano, Raúl R. Rodrigues-Diez, Marta Ruiz-Ortega
Published 2020-01-01

Interleuquina-17A: posible mediador y diana terapéutica en la hipertensión

by Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Macarena Orejudo, Laura Marquez-Exposito, Laura Santos, Sandra Rayego-Mateos, Elena Cantero-Navarro, Lucia Tejedor-Santamaria, Vanessa Marchant, Alberto Ortiz, Jesús Egido, Sergio Mezzano, Rafael Selgas, Juan F. Navarro-González, Jose M. Valdivielso, Carolina Lavoz, Marta Ruiz-Ortega
Published 2021-05-01

Interleukin-17A: Potential mediator and therapeutic target in hypertension

by Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Macarena Orejudo, Laura Marquez-Exposito, Laura Santos-Sanchez, Sandra Rayego-Mateos, Elena Cantero-Navarro, Lucia Tejedor-Santamaria, Vanessa Marchant, Alberto Ortiz, Jesús Egido, Sergio Mezzano, Rafael Selgas, Juan F. Navarro-González, Jose M. Valdivielso, Carolina Lavoz, Marta Ruiz-Ortega
Published 2021-05-01

Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis

by Laura Marquez-Exposito, Laura Marquez-Exposito, Carolina Lavoz, Raul R. Rodrigues-Diez, Raul R. Rodrigues-Diez, Sandra Rayego-Mateos, Sandra Rayego-Mateos, Macarena Orejudo, Macarena Orejudo, Elena Cantero-Navarro, Elena Cantero-Navarro, Alberto Ortiz, Alberto Ortiz, Jesús Egido, Jesús Egido, Rafael Selgas, Rafael Selgas, Sergio Mezzano, Marta Ruiz-Ortega, Marta Ruiz-Ortega
Published 2018-10-01

Interleukin 17A Participates in Renal Inflammation Associated to Experimental and Human Hypertension

by Macarena Orejudo, Macarena Orejudo, Raul R. Rodrigues-Diez, Raul R. Rodrigues-Diez, Raquel Rodrigues-Diez, Ana Garcia-Redondo, Laura Santos-Sánchez, Laura Santos-Sánchez, Javier Rández-Garbayo, Javier Rández-Garbayo, Pablo Cannata-Ortiz, Pablo Cannata-Ortiz, Adrian M. Ramos, Adrian M. Ramos, Alberto Ortiz, Alberto Ortiz, Rafael Selgas, Rafael Selgas, Sergio Mezzano, Carolina Lavoz, Marta Ruiz-Ortega, Marta Ruiz-Ortega
Published 2019-09-01