Aging and the rise of somatic cancer-associated mutations in normal tissues.

by Rosa Ana Risques, Scott R Kennedy
Published 2018-01-01

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage.

by Scott R Kennedy, Jesse J Salk, Michael W Schmitt, Lawrence A Loeb
Published 2013-01-01

Volatility of Mutator Phenotypes at Single Cell Resolution.

by Scott R Kennedy, Eric M Schultz, Thomas M Chappell, Brendan Kohrn, Gary M Knowels, Alan J Herr
Published 2015-04-01

Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ.

by Colby L Samstag, Jake G Hoekstra, Chiu-Hui Huang, Mark J Chaisson, Richard J Youle, Scott R Kennedy, Leo J Pallanck
Published 2018-11-01

Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles

by Ian T. Dowsett, Jessica L. Sneeden, Branden J. Olson, Jill McKay-Fleisch, Emma McAuley, Scott R. Kennedy, Alan J. Herr
Published 2021-01-01

Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations.

by Leslie S Itsara, Scott R Kennedy, Edward J Fox, Selina Yu, Joshua J Hewitt, Monica Sanchez-Contreras, Fernando Cardozo-Pelaez, Leo J Pallanck
Published 2014-02-01

A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster

by Maulik R Patel, Ganesh K Miriyala, Aimee J Littleton, Heiko Yang, Kien Trinh, Janet M Young, Scott R Kennedy, Yukiko M Yamashita, Leo J Pallanck, Harmit S Malik
Published 2016-08-01

Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila

by Simonetta Andreazza, Colby L. Samstag, Alvaro Sanchez-Martinez, Erika Fernandez-Vizarra, Aurora Gomez-Duran, Juliette J. Lee, Roberta Tufi, Michael J. Hipp, Elizabeth K. Schmidt, Thomas J. Nicholls, Payam A. Gammage, Patrick F. Chinnery, Michal Minczuk, Leo J. Pallanck, Scott R. Kennedy, Alexander J. Whitworth
Published 2019-07-01

Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

by Jianing Xu, Ed Reznik, Ho-Joon Lee, Gunes Gundem, Philip Jonsson, Judy Sarungbam, Anna Bialik, Francisco Sanchez-Vega, Chad J Creighton, Jake Hoekstra, Li Zhang, Peter Sajjakulnukit, Daniel Kremer, Zachary Tolstyka, Jozefina Casuscelli, Steve Stirdivant, Jie Tang, Nikolaus Schultz, Paul Jeng, Yiyu Dong, Wenjing Su, Emily H Cheng, Paul Russo, Jonathan A Coleman, Elli Papaemmanuil, Ying-Bei Chen, Victor E Reuter, Chris Sander, Scott R Kennedy, James J Hsieh, Costas A Lyssiotis, Satish K Tickoo, A Ari Hakimi
Published 2019-03-01