Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation

by Akihiko Oka, Yoshiyuki Mishima, Bo Liu, Jeremy W. Herzog, Erin C. Steinbach, Taku Kobayashi, Scott E. Plevy, R. Balfour Sartor
Published 2019-09-01

A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis.

by Houda Z Elloumi, Nitsan Maharshak, Kavitha N Rao, Taku Kobayashi, Hyungjin S Ryu, Marcus Mühlbauer, Fengling Li, Christian Jobin, Scott E Plevy
Published 2012-01-01

Dietary iron variably modulates assembly of the intestinal microbiota in colitis-resistant and colitis-susceptible mice

by Melissa Ellermann, Raad Z. Gharaibeh, Nitsan Maharshak, Ernesto Peréz-Chanona, Christian Jobin, Ian M. Carroll, Janelle C. Arthur, Scott E Plevy, Anthony A. Fodor, Cory R. Brouwer, R. Balfour Sartor
Published 2020-01-01

The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis.

by Carl L Manthey, Beverley A Moore, Yanqing Chen, Matthew J Loza, Xiang Yao, Hao Liu, Stanley M Belkowski, Holly Raymond-Parks, Paul J Dunford, Francisco Leon, Jennifer E Towne, Scott E Plevy
Published 2019-01-01