Paolo Sassone-Corsi
Paolo Sassone-Corsi (8 June 1956 – 22 July 2020) was an Italian
molecular biologist,
epigeneticist, and
researcher. He is known for his contributions in the areas of
transcriptional regulation,
epigenetics,
circadian biology, and
metabolic regulation. He is known for his contributions in the areas of
transcriptional regulation,
epigenetics, circadian biology, and
metabolic regulation. His research primarily focused on the mechanisms that regulate transcription and their relation to
metabolism and
circadian clocks. His work focused on understanding how the
circadian clock regulates
metabolic cycles. Most notably, he discovered that
SIRT1, a
histone deacetylase with a critical role in
gene expression and
metabolism, is able to regulate the activity of the
CLOCK protein. In 2011, Sassone-Corsi founded and directed the “Center for Epigenetics and Metabolism” at the
University of California, Irvine.
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