IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination.

by Mandana Zandian, Kevin R Mott, Sariah J Allen, Shuang Chen, Moshe Arditi, Homayon Ghiasi
Published 2011-02-01

Binding of HSV-1 glycoprotein K (gK) to signal peptide peptidase (SPP) is required for virus infectivity.

by Sariah J Allen, Kevin R Mott, Yoshiharu Matsuura, Kohji Moriishi, Konstantin G Kousoulas, Homayon Ghiasi
Published 2014-01-01

CD8α dendritic cells drive establishment of HSV-1 latency.

by Kevin R Mott, Sariah J Allen, Mandana Zandian, Bindu Konda, Behrooz G Sharifi, Clinton Jones, Steven L Wechsler, Terrence Town, Homayon Ghiasi
Published 2014-01-01

Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses.

by Kevin R Mott, Sariah J Allen, Mandana Zandian, Omid Akbari, Pedram Hamrah, Hadi Maazi, Steven L Wechsler, Arlene H Sharpe, Gordon J Freeman, Homayon Ghiasi
Published 2014-01-01

Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis

by Norman L. Lehman, Aisulu Usubalieva, Tong Lin, Sariah J. Allen, Quynh T. Tran, Bret C. Mobley, Roger E. McLendon, Matthew J. Schniederjan, Maria-Magdalena Georgescu, Marta Couce, Mohanpal S. Dulai, Jack M. Raisanen, Mousa Al Abbadi, Cheryl A. Palmer, Eyas M. Hattab, Brent A. Orr
Published 2019-03-01

SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression

by Tara T. Doucet-O’Hare, Brianna L. DiSanza, Catherine DeMarino, Abigail L. Atkinson, Jared S. Rosenblum, Lisa J. Henderson, Kory R. Johnson, Jeffrey Kowalak, Marta Garcia-Montojo, Sariah J. Allen, Brent A. Orr, Mariarita Santi, Tongguang Wang, Saeed Fathi, Myoung Hwa Lee, Kevon Sampson, Wenxue Li, Zhengping Zhuang, Avindra Nath
Published 2021-06-01