Pam3CSK4 Induces MMP-9 Expression in Human Monocytic THP-1 Cells

by Fatema Al-Rashed, Shihab Kochumon, Safa Usmani, Sardar Sindhu, Rasheed Ahmad
Published 2017-04-01

Palmitate-Induced MMP-9 Expression in the Human Monocytic Cells is Mediated through the TLR4-MyD88 Dependent Mechanism

by Sardar Sindhu, Areej Al-Roub, Merin Koshy, Reeby Thomas, Rasheed Ahmad
Published 2016-08-01

Obesity Is a Positive Modulator of IL-6R and IL-6 Expression in the Subcutaneous Adipose Tissue: Significance for Metabolic Inflammation.

by Sardar Sindhu, Reeby Thomas, Puthiyaveetil Shihab, Devarajan Sriraman, Kazem Behbehani, Rasheed Ahmad
Published 2015-01-01

Enhanced Adipose Expression of Interferon Regulatory Factor (IRF)-5 Associates with the Signatures of Metabolic Inflammation in Diabetic Obese Patients

by Sardar Sindhu, Shihab Kochumon, Reeby Thomas, Abdullah Bennakhi, Fahd Al-Mulla, Rasheed Ahmad
Published 2020-03-01

The Cooperative Induction of CCL4 in Human Monocytic Cells by TNF-α and Palmitate Requires MyD88 and Involves MAPK/NF-κB Signaling Pathways

by Sardar Sindhu, Shihab Kochumon, Steve Shenouda, Ajit Wilson, Fahd Al-Mulla, Rasheed Ahmad
Published 2019-09-01

Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF-κB/MAPK/ PI3K Signaling Systems

by Shihab Kochumon, Ajit Wilson, Betty Chandy, Steve Shenouda, Jaakko Tuomilehto, Sardar Sindhu, Rasheed Ahmad
Published 2018-04-01

Increasing the Duration of Light Physical Activity Ameliorates Insulin Resistance Syndrome in Metabolically Healthy Obese Adults

by Fatema Al-Rashed, Abdulwahab Alghaith, Rafaat Azim, Dawood AlMekhled, Reeby Thomas, Sardar Sindhu, Rasheed Ahmad
Published 2020-05-01

Increased Expression of the Innate Immune Receptor TLR10 in Obesity and Type-2 Diabetes: Association with ROS-Mediated Oxidative Stress

by Sardar Sindhu, Nadeem Akhter, Shihab Kochumon, Reeby Thomas, Ajit Wilson, Steve Shenouda, Jaakko Tuomilehto, Rasheed Ahmad
Published 2018-01-01

TNF-α Increases IP-10 Expression in MCF-7 Breast Cancer Cells via Activation of the JNK/c-Jun Pathways

by Shihab Kochumon, Amnah Al-Sayyar, Texy Jacob, Amal Hasan, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Published 2021-09-01

MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress

by Sardar Sindhu, Nadeem Akhter, Ajit Wilson, Reeby Thomas, Hossein Arefanian, Ashraf Al Madhoun, Fahd Al-Mulla, Rasheed Ahmad
Published 2020-07-01

Increased Adipose Tissue Expression of Interferon Regulatory Factor (IRF)-5 in Obesity: Association with Metabolic Inflammation

by Sardar Sindhu, Reeby Thomas, Shihab Kochumon, Ajit Wilson, Mohamed Abu-Farha, Abdullah Bennakhi, Fahd Al-Mulla, Rasheed Ahmad
Published 2019-11-01

MIP-1α Induction by Palmitate in the Human Monocytic Cells Implicates TLR4 Signaling Mechanism

by Rasheed Ahmad, Nadeem Akhter, Areej Al-Roub, Shihab Kochumon, Ajit Wilson, Reeby Thomas, Shamsha Ali, Jaakko Tuomilehto, Sardar Sindhu
Published 2019-02-01

TNF-α Drives the CCL4 Expression in Human Monocytic Cells: Involvement of the SAPK/JNK and NF-κB Signaling Pathways

by Rasheed Ahmad, Shihab Kochumon, Betty Chandy, Steve Shenouda, Merin Koshy, Amal Hasan, Hossein Arefanian, Fahd Al-Mulla, Sardar Sindhu
Published 2019-04-01

Oxidative Stress Induces Expression of the Toll-Like Receptors (TLRs) 2 and 4 in the Human Peripheral Blood Mononuclear Cells: Implications for Metabolic Inflammation

by Nadeem Akhter, Ashraf Madhoun, Hossein Arefanian, Ajit Wilson, Shihab Kochumon, Reeby Thomas, Steve Shenouda, Fahd Al-Mulla, Rasheed Ahmad, Sardar Sindhu
Published 2019-06-01

Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton’s Jelly-Derived Mesenchymal Stem Cells

by Ashraf Al Madhoun, Sulaiman K. Marafie, Dania Haddad, Motasem Melhem, Mohamed Abu-Farha, Hamad Ali, Sardar Sindhu, Maher Atari, Fahd Al-Mulla
Published 2020-09-01

Short Chain Fatty Acid Acetate Increases TNFα-Induced MCP-1 Production in Monocytic Cells via ACSL1/MAPK/NF-κB Axis

by Areej Al-Roub, Nadeem Akhter, Amnah Al-Sayyar, Ajit Wilson, Reeby Thomas, Shihab Kochumon, Fatema Al-Rashed, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Published 2021-07-01

Stearic Acid and TNF-α Co-Operatively Potentiate MIP-1α Production in Monocytic Cells via MyD88 Independent TLR4/TBK/IRF3 Signaling Pathway

by Shihab Kochumon, Hossein Arefanian, Rafaat Azim, Steve Shenouda, Texy Jacob, Nermeen Abu Abu Khalaf, Fatema Al-Rashed, Amal Hasan, Sardar Sindhu, Fahd Al-Mulla, Rasheed Ahmad
Published 2020-10-01

Repetitive Intermittent Hyperglycemia Drives the M1 Polarization and Inflammatory Responses in THP-1 Macrophages Through the Mechanism Involving the TLR4-IRF5 Pathway

by Fatema Al-Rashed, Sardar Sindhu, Hossein Arefanian, Ashraf Al Madhoun, Shihab Kochumon, Reeby Thomas, Sarah Al-Kandari, Abdulwahab Alghaith, Texy Jacob, Fahd Al-Mulla, Rasheed Ahmad
Published 2020-08-01

Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals

by Fatema Al-Rashed, Sardar Sindhu, Ashraf Al Madhoun, Zunair Ahmad, Dawood AlMekhled, Rafaat Azim, Sarah Al-Kandari, Maziad Al-Abdul Wahid, Fahd Al-Mulla, Rasheed Ahmad
Published 2021-07-01

Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells

by Fatema Al-Rashed, Zunair Ahmad, Ashley J. Snider, Reeby Thomas, Shihab Kochumon, Motasem Melhem, Sardar Sindhu, Lina M. Obeid, Fahd Al-Mulla, Yusuf A. Hannun, Rasheed Ahmad
Published 2021-04-01