In silico, in vitro, and in vivo Approaches to Identify Molecular Players in Fragile X Tremor and Ataxia Syndrome

by Saif N. Haify, Teresa Botta-Orfila, Renate K. Hukema, Gian Gaetano Tartaglia, Gian Gaetano Tartaglia, Gian Gaetano Tartaglia, Gian Gaetano Tartaglia, Gian Gaetano Tartaglia
Published 2020-03-01

Lack of a Clear Behavioral Phenotype in an Inducible FXTAS Mouse Model Despite the Presence of Neuronal FMRpolyG-Positive Aggregates

by Saif N. Haify, Ruchira S. D. Mankoe, Ruchira S. D. Mankoe, Valerie Boumeester, Esmay C. van der Toorn, Rob F. M. Verhagen, Rob Willemsen, Renate K. Hukema, Renate K. Hukema, Laurens W. J. Bosman
Published 2020-12-01

Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pa...

by H. Jürgen Wenzel, Karl D. Murray, Saif N. Haify, Michael R. Hunsaker, Jared J. Schwartzer, Kyoungmi Kim, Albert R. La Spada, Bryce L. Sopher, Paul J. Hagerman, Christopher Raske, Lies-Anne W.F.M. Severijnen, Rob Willemsen, Renate K. Hukema, Robert F. Berman
Published 2019-02-01