Assessing antiretroviral drug (ARV) bioavailability in HIV tissue reservoirs using in vitro and in vivo pharmacokinetic (PK) studies with human primary lymphoid endothelial cells a...

by S. Dyavar, A. Podany, N. Gautam, Y. Alnouti, C. Fletcher, L. Winchester, T. Mykris, J. Weinhold, K. Campbell
Published 2017-12-01

Cryopreservation of microglia enables single-cell RNA sequencing with minimal effects on disease-related gene expression patterns

by Brenda Morsey, Meng Niu, Shetty Ravi Dyavar, Courtney V. Fletcher, Benjamin G. Lamberty, Katy Emanuel, Anna Fangmeier, Howard S. Fox
Published 2021-04-01

Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation

by Ibrahim IM, Bade AN, Lin Z, Soni D, Wojtkiewicz M, Dyavar Shetty BL, Gautam N, McMillan JM, Alnouti Y, Edagwa BJ, Gendelman HE
Published 2019-08-01

Role of toll-like receptor 7/8 pathways in regulation of interferon response and inflammatory mediators during SARS-CoV2 infection and potential therapeutic options

by Shetty Ravi Dyavar, Rahul Singh, Rohini Emani, Ganesh P. Pawar, Vinod D. Chaudhari, Anthony T. Podany, Sean N. Avedissian, Courtney V. Fletcher, Deepak B. Salunke
Published 2021-09-01

Enhancing antiretroviral drug penetration into lymph nodes through intramuscular and subcutaneous routes of administration in BALB/c mice

by Shetty Ravi Dyavar, Sushil Kumar, Nagsen Gautam, Anthony T. Podany, Lee C. Winchester, Jonathan A. Weinhold, Timothy M. Mykris, Kayla M. Campbell, Palanisamy Nallasamy, Yazen Alnouti, Courtney V. Fletcher
Published 2019-12-01

Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles

by Denise A. Cobb, Nathan Smith, Suyash Deodhar, Aditya N. Bade, Nagsen Gautam, Bhagya Laxmi Dyavar Shetty, JoEllyn McMillan, Yazen Alnouti, Samuel M. Cohen, Howard E. Gendelman, Benson Edagwa
Published 2021-09-01

Lipophilic nanocrystal prodrug-release defines the extended pharmacokinetic profiles of a year-long cabotegravir

by Nagsen Gautam, JoEllyn M. McMillan, Devendra Kumar, Aditya N. Bade, Qiaoyu Pan, Tanmay A. Kulkarni, Wenkuan Li, Brady Sillman, Nathan A. Smith, Bhagya L. Dyavar Shetty, Adam Szlachetka, Benson J. Edagwa, Howard E. Gendelman, Yazen Alnouti
Published 2021-06-01

Evaluation of the safety and immunomodulatory effects of sargramostim in a randomized, double-blind phase 1 clinical Parkinson’s disease trial

by Howard E. Gendelman, Yuning Zhang, Pamela Santamaria, Katherine E. Olson, Charles R. Schutt, Danish Bhatti, Bhagya Laxmi Dyavar Shetty, Yaman Lu, Katherine A. Estes, David G. Standaert, Elizabeth Heinrichs-Graham, LuAnn Larson, Jane L. Meza, Matthew Follett, Erica Forsberg, Gary Siuzdak, Tony W. Wilson, Carolyn Peterson, R. Lee Mosley
Published 2017-03-01