Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism

by Khateb Mamduh, Ruimi Nili, Khamisie Hazem, Najajreh Yousef, Mian Afsar, Metodieva Anna, Ruthardt Martin, Mahajna Jamal
Published 2012-11-01

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I

by Mian Afsar, Metodieva Anna, Badura Susanne, Khateb Mamduh, Ruimi Nili, Najajreh Yousef, Ottmann Oliver, Mahajna Jamal, Ruthardt Martin
Published 2012-09-01