Deletion study of DNA topoisomerase IB from Leishmania donovani: searching for a minimal functional heterodimer.

by Rosario Díaz González, Yolanda Pérez Pertejo, David Ordóñez, Rafael Balaña-Fouce, Rosa M Reguera
Published 2007-01-01

The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing.

by Rosario Diaz-Gonzalez, F Matthew Kuhlmann, Cristina Galan-Rodriguez, Luciana Madeira da Silva, Manuel Saldivia, Caitlin E Karver, Ana Rodriguez, Stephen M Beverley, Miguel Navarro, Michael P Pollastri
Published 2011-08-01

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents.

by Dana M Klug, Rosario Diaz-Gonzalez, Guiomar Pérez-Moreno, Gloria Ceballos-Pérez, Raquel García-Hernández, Veronica Gomez-Pérez, Luis Miguel Ruiz-Pérez, Domingo I Rojas-Barros, Francisco Gamarro, Dolores González-Pacanowska, María S Martínez-Martínez, Pilar Manzano, Lori Ferrins, Conor R Caffrey, Miguel Navarro, Michael P Pollastri
Published 2019-02-01