Cancer prevention in developing countries: a vision for preserving health in Mexico

by Ronald A DePinho, Ernest Hawk
Published 2016-03-01

Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis.

by Xiwen Xiong, Rongya Tao, Ronald A DePinho, X Charlie Dong
Published 2013-01-01

Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6[S]

by Rongya Tao, Xiwen Xiong, Ronald A. DePinho, Chu-Xia Deng, X. Charlie Dong
Published 2013-10-01

SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2

by Amir Kumar Singh, Prashant Khare, Abeer Obaid, Kevin P. Conlon, Venkatesha Basrur, Ronald A. DePinho, K. Venuprasad
Published 2018-10-01

PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis

by Sohee Jun, Sunhye Lee, Han-Cheon Kim, Christopher Ng, Andrea M. Schneider, Hong Ji, Haoqiang Ying, Huamin Wang, Ronald A. DePinho, Jae-Il Park
Published 2013-10-01

Transcription factor FoxO1 is essential for enamel biomineralization.

by Ross A Poché, Ramaswamy Sharma, Monica D Garcia, Aya M Wada, Mark J Nolte, Ryan S Udan, Ji-Hye Paik, Ronald A DePinho, John D Bartlett, Mary E Dickinson
Published 2012-01-01

Targeting Cathepsin E in Pancreatic Cancer by a Small Molecule Allows In Vivo Detection

by Edmund J. Keliher, Thomas Reiner, Sarah Earley, Jenna Klubnick, Carlos Tassa, Andrew J. Lee, Sridhar Ramaswamy, Nabeel Bardeesy, Douglas Hanahan, Ronald A. DePinho, Cesar M. Castro, Ralph Weissleder
Published 2013-07-01

FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis

by Hamza M Al‐Tamari, Swati Dabral, Anja Schmall, Pouya Sarvari, Clemens Ruppert, Jihye Paik, Ronald A DePinho, Friedrich Grimminger, Oliver Eickelberg, Andreas Guenther, Werner Seeger, Rajkumar Savai, Soni S Pullamsetti
Published 2018-02-01

Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway

by Dan He, Hongguang Wu, Jinnan Xiang, Xinsen Ruan, Peike Peng, Yuanyuan Ruan, Ye-Guang Chen, Yibin Wang, Qiang Yu, Hongbing Zhang, Samy L. Habib, Ronald A. De Pinho, Huijuan Liu, Baojie Li
Published 2020-01-01

Correction: Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy

by Masayuki Nitta, David Kozono, Richard Kennedy, Jayne Stommel, Kimberly Ng, Pascal O. Zinn, Deepa Kushwaha, Santosh Kesari, Frank Furnari, Katherine A. Hoadley, Lynda Chin, Ronald A. DePinho, Webster K. Cavenee, Alan D'Andrea, Clark C. Chen
Published 2011-01-01

Correction: Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy.

by Masayuki Nitta, David Kozono, Richard Kennedy, Jayne Stommel, Kimberly Ng, Pascal O. Zinn, Deepa Kushwaha, Santosh Kesari, Frank Furnari, Katherine A. Hoadley, Lynda Chin, Ronald A. DePinho, Webster K. Cavenee, Alan D'Andrea, Clark C. Chen
Published 2011-01-01

Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy.

by Masayuki Nitta, David Kozono, Richard Kennedy, Jayne Stommel, Kimberly Ng, Pascal O Zinn, Deepa Kushwaha, Santosh Kesari, Maria-del-Mar Inda, Jill Wykosky, Frank Furnari, Katherine A Hoadley, Lynda Chin, Ronald A DePinho, Webster K Cavenee, Alan D'Andrea, Clark C Chen
Published 2010-01-01

Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

by Huai-Qiang Ju, Haoqiang Ying, Tian Tian, Jianhua Ling, Jie Fu, Yu Lu, Min Wu, Lifeng Yang, Abhinav Achreja, Gang Chen, Zhuonan Zhuang, Huamin Wang, Deepak Nagrath, Jun Yao, Mien-Chie Hung, Ronald A. DePinho, Peng Huang, Rui-Hua Xu, Paul J. Chiao
Published 2017-02-01

Effective combinatorial immunotherapy for penile squamous cell carcinoma

by Tianhe Huang, Xi Cheng, Jad Chahoud, Ahmed Sarhan, Pheroze Tamboli, Priya Rao, Ming Guo, Ganiraju Manyam, Li Zhang, Yu Xiang, Leng Han, Xiaoying Shang, Pingna Deng, Yanting Luo, Xuemin Lu, Shan Feng, Magaly Martinez Ferrer, Y. Alan Wang, Ronald A. DePinho, Curtis A. Pettaway, Xin Lu
Published 2020-05-01

FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase

by Khanh V. Doan, Ann W. Kinyua, Dong Joo Yang, Chang Mann Ko, Sang Hyun Moh, Ko Eun Shong, Hail Kim, Sang-Kyu Park, Dong-Hoon Kim, Inki Kim, Ji-Hye Paik, Ronald A. DePinho, Seul Gi Yoon, Il Yong Kim, Je Kyung Seong, Yun-Hee Choi, Ki Woo Kim
Published 2016-09-01

A mouse to human search for plasma proteome changes associated with pancreatic tumor development.

by Vitor M Faca, Kenneth S Song, Hong Wang, Qing Zhang, Alexei L Krasnoselsky, Lisa F Newcomb, Ruben R Plentz, Sushma Gurumurthy, Mark S Redston, Sharon J Pitteri, Sandra R Pereira-Faca, Renee C Ireton, Hiroyuki Katayama, Veronika Glukhova, Douglas Phanstiel, Dean E Brenner, Michelle A Anderson, David Misek, Nathalie Scholler, Nicole D Urban, Matt J Barnett, Cim Edelstein, Gary E Goodman, Mark D Thornquist, Martin W McIntosh, Ronald A DePinho, Nabeel Bardeesy, Samir M Hanash
Published 2008-06-01

Telomere dysfunction activates YAP1 to drive tissue inflammation

by Deepavali Chakravarti, Baoli Hu, Xizeng Mao, Asif Rashid, Jiexi Li, Jun Li, Wen-ting Liao, Elizabeth M. Whitley, Prasenjit Dey, Pingping Hou, Kyle A. LaBella, Andrew Chang, Guocan Wang, Denise J. Spring, Pingna Deng, Di Zhao, Xin Liang, Zhengdao Lan, Yiyun Lin, Sharmistha Sarkar, Christopher Terranova, Yonathan Lissanu Deribe, Sarah E. Blutt, Pablo Okhuysen, Jianhua Zhang, Eduardo Vilar, Ole Haagen Nielsen, Andrew Dupont, Mamoun Younes, Kalyani R. Patel, Noah F. Shroyer, Kunal Rai, Mary K. Estes, Y. Alan Wang, Alison A. Bertuch, Ronald A. DePinho
Published 2020-09-01

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

by Yuting Sun, Madhavi Bandi, Timothy Lofton, Melinda Smith, Christopher A. Bristow, Alessandro Carugo, Norma Rogers, Paul Leonard, Qing Chang, Robert Mullinax, Jing Han, Xi Shi, Sahil Seth, Brooke A. Meyers, Meredith Miller, Lili Miao, Xiaoyan Ma, Ningping Feng, Virginia Giuliani, Mary Geck Do, Barbara Czako, Wylie S. Palmer, Faika Mseeh, John M. Asara, Yongying Jiang, Pietro Morlacchi, Shuping Zhao, Michael Peoples, Trang N. Tieu, Marc O. Warmoes, Philip L. Lorenzi, Florian L. Muller, Ronald A. DePinho, Giulio F. Draetta, Carlo Toniatti, Philip Jones, Timothy P. Heffernan, Joseph R. Marszalek
Published 2019-01-01