Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum

by Marvin Duvalsaint, Melissa D. Conrad, Stephen Tukwasibwe, Patrick K. Tumwebaze, Jennifer Legac, Roland A. Cooper, Philip J. Rosenthal
Published 2021-06-01

Genome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt gene.

by Hongying Jiang, Jigar J Patel, Ming Yi, Jianbing Mu, Jinhui Ding, Robert Stephens, Roland A Cooper, Michael T Ferdig, Xin-zhuan Su
Published 2008-06-01

Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation

by Kirthana M. V. Sindhe, Wesley Wu, Jenny Legac, Yong-Kang Zhang, Eric E. Easom, Roland A. Cooper, Jacob J. Plattner, Yvonne R. Freund, Joseph L. DeRisi, Philip J. Rosenthal
Published 2020-01-01

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

by Satish K. Dhingra, Devasha Redhi, Jill M. Combrinck, Tomas Yeo, John Okombo, Philipp P. Henrich, Annie N. Cowell, Purva Gupta, Matthew L. Stegman, Jonathan M. Hoke, Roland A. Cooper, Elizabeth Winzeler, Sachel Mok, Timothy J. Egan, David A. Fidock, Thomas E. Wellems
Published 2017-05-01

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

by Ebere Sonoiki, Caroline L. Ng, Marcus C. S. Lee, Denghui Guo, Yong-Kang Zhang, Yasheen Zhou, M. R. K. Alley, Vida Ahyong, Laura M. Sanz, Maria Jose Lafuente-Monasterio, Chen Dong, Patrick G. Schupp, Jiri Gut, Jenny Legac, Roland A. Cooper, Francisco-Javier Gamo, Joseph DeRisi, Yvonne R. Freund, David A. Fidock, Philip J. Rosenthal
Published 2017-03-01

Drug susceptibility of Plasmodium falciparum in eastern Uganda: a longitudinal phenotypic and genotypic study

by Patrick K Tumwebaze, MS, Thomas Katairo, MS, Martin Okitwi, BS, Oswald Byaruhanga, Dip, Stephen Orena, BS, Victor Asua, MS, Marvin Duvalsaint, PhD, Jennifer Legac, BS, Sevil Chelebieva, BS, Frida G Ceja, BS, Stephanie A Rasmussen, MS, Melissa D Conrad, PhD, Samuel L Nsobya, PhD, Ozkan Aydemir, PhD, Jeffrey A Bailey, PhD, Brett R Bayles, PhD, Philip J Rosenthal, ProfMD, Roland A Cooper, ProfPhD
Published 2021-09-01