Combining Notch inhibition with current therapies for breast cancer treatment

by Keith Brennan, Robert B. Clarke
Published 2013-01-01

A Role for Notch Signalling in Breast Cancer and Endocrine Resistance

by Ahmet Acar, Bruno M. Simões, Robert B. Clarke, Keith Brennan
Published 2016-01-01

Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status.

by Gillian Farnie, Pamela M Willan, Robert B Clarke, Nigel J Bundred
Published 2013-01-01

G Protein-Coupled Receptors at the Crossroad between Physiologic and Pathologic Angiogenesis: Old Paradigms and Emerging Concepts

by Ernestina M. De Francesco, Federica Sotgia, Robert B. Clarke, Michael P. Lisanti, Marcello Maggiolini
Published 2017-12-01

Wnt pathway activity in breast cancer sub-types and stem-like cells.

by Rebecca Lamb, Matthew P Ablett, Katherine Spence, Göran Landberg, Andrew H Sims, Robert B Clarke
Published 2013-01-01

GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment

by Ernestina M. De Francesco, Andrew H. Sims, Marcello Maggiolini, Federica Sotgia, Michael P. Lisanti, Robert B. Clarke
Published 2017-12-01

Targeting Endometrial Cancer Stem Cell Activity with Metformin Is Inhibited by Patient-Derived Adipocyte-Secreted Factors

by Sarah J. Kitson, Matthew Rosser, Deborah P. Fischer, Kay M. Marshall, Robert B. Clarke, Emma J. Crosbie
Published 2019-05-01

Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: an experimentally supported mathematical model.

by Zvia Agur, Oleg U Kirnasovsky, Genadiy Vasserman, Lilach Tencer-Hershkowicz, Yuri Kogan, Hannah Harrison, Rebecca Lamb, Robert B Clarke
Published 2011-01-01

FAK inhibition alone or in combination with adjuvant therapies reduces cancer stem cell activity

by Simon Timbrell, Hosam Aglan, Angela Cramer, Phil Foden, David Weaver, Jonathan Pachter, Aoife Kilgallon, Robert B. Clarke, Gillian Farnie, Nigel J. Bundred
Published 2021-05-01

Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells

by Ana Lazaro-Carrillo, Macarena Calero, Antonio Aires, Aitziber L. Cortajarena, Bruno M. Simões, Alfonso Latorre, Álvaro Somoza, Robert B. Clarke, Rodolfo Miranda, Angeles Villanueva
Published 2020-05-01

Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors

by Bruno M. Simões, Bertram Kohler, Robert B. Clarke, Jacqui Stringer, Lily Novak-Frazer, Keely Young, Riina Rautemaa-Richardson, Giorgia Zucchini, Anne Armstrong, Sacha J. Howell
Published 2018-03-01

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

by Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell
Published 2019-11-01

FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4

by Lana McClements, Stephanie Annett, Anita Yakkundi, Martin O’Rourke, Andrea Valentine, Nermeen Moustafa, Abdelrahim Alqudah, Bruno M. Simões, Fiona Furlong, Amy Short, Stuart A. McIntosh, Helen O. McCarthy, Robert B. Clarke, Tracy Robson
Published 2019-04-01

Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors

by Karsten Bach, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A. Lazarus, Mona Shehata, Bruno M. Simões, Alice R. Greenhalgh, Sacha J. Howell, Robert B. Clarke, Carlos Caldas, Timotheus Y. F. Halim, John C. Marioni, Walid T. Khaled
Published 2021-03-01

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

by Rachel Eyre, Denis G. Alférez, Angélica Santiago-Gómez, Kath Spence, James C. McConnell, Claire Hart, Bruno M. Simões, Diane Lefley, Claudia Tulotta, Joanna Storer, Austin Gurney, Noel Clarke, Mick Brown, Sacha J. Howell, Andrew H. Sims, Gillian Farnie, Penelope D. Ottewell, Robert B. Clarke
Published 2019-11-01

Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity

by Bruno M. Simões, Ciara S. O’Brien, Rachel Eyre, Andreia Silva, Ling Yu, Aida Sarmiento-Castro, Denis G. Alférez, Kath Spence, Angélica Santiago-Gómez, Francesca Chemi, Ahmet Acar, Ashu Gandhi, Anthony Howell, Keith Brennan, Lisa Rydén, Stefania Catalano, Sebastiano Andó, Julia Gee, Ahmet Ucar, Andrew H. Sims, Elisabetta Marangoni, Gillian Farnie, Göran Landberg, Sacha J. Howell, Robert B. Clarke
Published 2015-09-01