The Role of AMPK Signaling in Brown Adipose Tissue Activation

by Jamie I. van der Vaart, Mariëtte R. Boon, Riekelt H. Houtkooper
Published 2021-05-01

Identification of enzymes involved in oxidation of phenylbutyrate

by Neža Palir, Jos P.N. Ruiter, Ronald J.A. Wanders, Riekelt H. Houtkooper
Published 2017-05-01

From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs

by Rebecca L McIntyre, Eileen G Daniels, Marte Molenaars, Riekelt H Houtkooper, Georges E Janssens
Published 2019-09-01

Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction

by Sanne van der Rijt, Marte Molenaars, Rebecca L. McIntyre, Georges E. Janssens, Riekelt H. Houtkooper
Published 2020-11-01

Biological Age Prediction From Wearable Device Movement Data Identifies Nutritional and Pharmacological Interventions for Healthy Aging

by Rebecca L. McIntyre, Mizanur Rahman, Siva A. Vanapalli, Siva A. Vanapalli, Riekelt H. Houtkooper, Georges E. Janssens
Published 2021-07-01

Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice

by Eline N. Kuipers, Andrea D. van Dam, Ntsiki M. Held, Isabel M. Mol, Riekelt H. Houtkooper, Patrick C.N. Rensen, Mariëtte R. Boon
Published 2018-06-01

Skeletal muscle in healthy humans exhibits a day-night rhythm in lipid metabolism

by Ntsiki M. Held, Jakob Wefers, Michel van Weeghel, Sabine Daemen, Jan Hansen, Frédéric M. Vaz, Dirk van Moorsel, Matthijs K.C. Hesselink, Riekelt H. Houtkooper, Patrick Schrauwen
Published 2020-07-01

Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation

by Marit Wiersma, Denise M.S. van Marion, Rob C.I. Wüst, Riekelt H. Houtkooper, Deli Zhang, Natasja M.S. de Groot, Robert H. Henning, Bianca J.J.M. Brundel
Published 2019-10-01

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

by Norman Moullan, Laurent Mouchiroud, Xu Wang, Dongryeol Ryu, Evan G. Williams, Adrienne Mottis, Virginija Jovaisaite, Michael V. Frochaux, Pedro M. Quiros, Bart Deplancke, Riekelt H. Houtkooper, Johan Auwerx
Published 2015-03-01

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion.

by Yasmine J Liu, Georges E Janssens, Rebecca L McIntyre, Marte Molenaars, Rashmi Kamble, Arwen W Gao, Aldo Jongejan, Michel van Weeghel, Alyson W MacInnes, Riekelt H Houtkooper
Published 2019-03-01

A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor

by Judith Giroud-Gerbetant, Magali Joffraud, Maria Pilar Giner, Angelique Cercillieux, Simona Bartova, Mikhail V. Makarov, Rubén Zapata-Pérez, José L. Sánchez-García, Riekelt H. Houtkooper, Marie E. Migaud, Sofia Moco, Carles Canto
Published 2019-12-01

Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

by Ntsiki M. Held, M. Renate Buijink, Hyung L. Elfrink, Sander Kooijman, Georges E. Janssens, Angela C. M. Luyf, Mia L. Pras-Raves, Frédéric M. Vaz, Stephan Michel, Riekelt H. Houtkooper, Michel van Weeghel
Published 2021-03-01

The gut microbiota as a modulator of innate immunity during melioidosis.

by Jacqueline M Lankelma, Emma Birnie, Tassili A F Weehuizen, Brendon P Scicluna, Clara Belzer, Riekelt H Houtkooper, Joris J T H Roelofs, Alex F de Vos, Tom van der Poll, Andries E Budding, W Joost Wiersinga
Published 2017-04-01

A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans

by Arwen W. Gao, Iliana A. Chatzispyrou, Rashmi Kamble, Yasmine J. Liu, Katharina Herzog, Reuben L. Smith, Henk van Lenthe, Martin A. T. Vervaart, Arno van Cruchten, Angela C. Luyf, Antoine van Kampen, Mia L. Pras-Raves, Frédéric M. Vaz, Riekelt H. Houtkooper
Published 2017-05-01

The Antibiotic Doxycycline Impairs Cardiac Mitochondrial and Contractile Function

by Rob C. I. Wüst, Bram F. Coolen, Ntsiki M. Held, Mariah R. R. Daal, Vida Alizadeh Tazehkandi, Luciënne Baks-te Bulte, Marit Wiersma, Diederik W. D. Kuster, Bianca J. J. M. Brundel, Michel van Weeghel, Gustav J. Strijkers, Riekelt H. Houtkooper
Published 2021-04-01

Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity

by Yuanqing Gao, Andrés Vidal-Itriago, Martin J. Kalsbeek, Clarita Layritz, Cristina García-Cáceres, Robby Zachariah Tom, Thomas O. Eichmann, Frédéric M. Vaz, Riekelt H. Houtkooper, Nicole van der Wel, Arthur J. Verhoeven, Jie Yan, Andries Kalsbeek, Robert H. Eckel, Susanna M. Hofmann, Chun-Xia Yi
Published 2017-09-01

Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy.

by Wino J Wijnen, Ingeborg van der Made, Stephanie van den Oever, Monika Hiller, Bouke A de Boer, Daisy I Picavet, Iliana A Chatzispyrou, Riekelt H Houtkooper, Anke J Tijsen, Jaco Hagoort, Henk van Veen, Vincent Everts, Jan M Ruijter, Yigal M Pinto, Esther E Creemers
Published 2014-01-01

Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Do not Improve with Carnitine Supplementation

by Arie O. Verkerk, Arie O. Verkerk, Suzan J. G. Knottnerus, Suzan J. G. Knottnerus, Vincent Portero, Jeannette C. Bleeker, Jeannette C. Bleeker, Sacha Ferdinandusse, Kaomei Guan, Lodewijk IJlst, Gepke Visser, Gepke Visser, Ronald J. A. Wanders, Frits A. Wijburg, Connie R. Bezzina, Isabella Mengarelli, Riekelt H. Houtkooper
Published 2021-01-01

Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Can Be Improved by Lowering Accumulation of Fatty Acid Oxidation Intermediates

by Suzan J. G. Knottnerus, Isabella Mengarelli, Rob C. I. Wüst, Antonius Baartscheer, Jeannette C. Bleeker, Ruben Coronel, Sacha Ferdinandusse, Kaomei Guan, Lodewijk IJlst, Wener Li, Xiaojing Luo, Vincent M. Portero, Ying Ulbricht, Gepke Visser, Ronald J. A. Wanders, Frits A. Wijburg, Arie O. Verkerk, Riekelt H. Houtkooper, Connie R. Bezzina
Published 2020-04-01

Modeling Meets Metabolomics—The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism Caenorhabditis elegans

by Michael Witting, Michael Witting, Janna Hastings, Nicolas Rodriguez, Chintan J. Joshi, Jake P. N. Hattwell, Paul R. Ebert, Michel van Weeghel, Arwen W. Gao, Michael J. O. Wakelam, Riekelt H. Houtkooper, Abraham Mains, Nicolas Le Novère, Sean Sadykoff, Frank Schroeder, Nathan E. Lewis, Nathan E. Lewis, Horst-Joachim Schirra, Christoph Kaleta, Olivia Casanueva
Published 2018-11-01