Toxicity and management in CAR T-cell therapy

by Challice L Bonifant, Hollie J Jackson, Renier J Brentjens, Kevin J Curran
Published 2016-01-01

Acute myeloid leukemia arising from a donor derived premalignant hematopoietic clone: A possible mechanism for the origin of leukemia in donor cells

by Mark A. Dickson, Esperanza B. Papadopoulos, Cyrus V. Hedvat, Suresh C. Jhanwar, Renier J. Brentjens
Published 2014-01-01

CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function

by Nicholas F. Kuhn, Andrea V. Lopez, Xinghuo Li, Winson Cai, Anthony F. Daniyan, Renier J. Brentjens
Published 2020-12-01

Modeling anti-CD19 CAR T cell therapy in humanized mice with human immunity and autologous leukemiaResearch in context

by Chun-Hui Jin, Jinxing Xia, Sarwish Rafiq, Xin Huang, Zheng Hu, Xianzheng Zhou, Renier J. Brentjens, Yong-Guang Yang
Published 2019-01-01

The Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of acute leukemia

by Michael M Boyiadzis, Ivan Aksentijevich, Daniel A Arber, Renier J Brentjens, Ephraim J Fuchs, Linda J Fukas, Steven D Gore, Mark R Litzow, John M Pagel, Martin S Tallman
Published 2020-07-01

Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition

by Oladapo O. Yeku, Oladapo O. Yeku, Thapi Dharma Rao, Ian Laster, Artem Kononenko, Terence J. Purdon, Pei Wang, Ziyou Cui, Hong Liu, Renier J. Brentjens, David Spriggs, David Spriggs
Published 2021-04-01

In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice.

by Nadia Terziyska, Catarina Castro Alves, Volker Groiss, Katja Schneider, Katarina Farkasova, Manfred Ogris, Ernst Wagner, Harald Ehrhardt, Renier J Brentjens, Udo zur Stadt, Martin Horstmann, Leticia Quintanilla-Martinez, Irmela Jeremias
Published 2012-01-01

Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages

by Mei Song, Oladapo O. Yeku, Sarwish Rafiq, Terence Purdon, Xue Dong, Lijing Zhu, Tuo Zhang, Huan Wang, Ziqi Yu, Junhua Mai, Haifa Shen, Briana Nixon, Ming Li, Renier J. Brentjens, Xiaojing Ma
Published 2020-12-01

Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance

by Michael M. Boyiadzis, Madhav V. Dhodapkar, Renier J. Brentjens, James N. Kochenderfer, Sattva S. Neelapu, Marcela V. Maus, David L. Porter, David G. Maloney, Stephan A. Grupp, Crystal L. Mackall, Carl H. June, Michael R. Bishop
Published 2018-12-01

Screening Clinical Cell Products for Replication Competent Retrovirus: The National Gene Vector Biorepository Experience

by Kenneth Cornetta, Lisa Duffy, Steven A. Feldman, Crystal L. Mackall, Marco L. Davila, Kevin J. Curran, Richard P. Junghans, Jean Yuh Tang, James N. Kochenderfer, Roisin O’Cearbhaill, Gary Archer, Hans-Peter Kiem, Nirali N. Shah, Cindy Delbrook, Rosie Kaplan, Renier J. Brentjens, Isabelle Rivière, Michel Sadelain, Steven A. Rosenberg
Published 2018-09-01

Depletion of high-content CD14+ cells from apheresis products is critical for successful transduction and expansion of CAR T cells during large-scale cGMP manufacturing

by Xiuyan Wang, Oriana Borquez-Ojeda, Jolanta Stefanski, Fang Du, Jinrong Qu, Jagrutiben Chaudhari, Keyur Thummar, Mingzhu Zhu, Ling-bo Shen, Melanie Hall, Paridhi Gautam, Yongzeng Wang, Brigitte Sénéchal, Devanjan Sikder, Prasad S. Adusumilli, Renier J. Brentjens, Kevin Curran, Mark B. Geyer, Sham Mailankhody, Roisin O’Cearbhaill, Jae H. Park, Craig Sauter, Susan Slovin, Eric L. Smith, Isabelle Rivière
Published 2021-09-01