Protein Quality Control in the Nucleus

by Sofie V. Nielsen, Esben G. Poulsen, Caio A. Rebula, Rasmus Hartmann-Petersen
Published 2014-07-01

Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

by Wouter Boomsma, Sofie V. Nielsen, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen, Lars Ellgaard
Published 2016-02-01

HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitin.

by Esben G Poulsen, Cornelia Steinhauer, Michael Lees, Anne-Marie Lauridsen, Lars Ellgaard, Rasmus Hartmann-Petersen
Published 2012-01-01

Co-Chaperones in Targeting and Delivery of Misfolded Proteins to the 26S Proteasome

by Amanda B. Abildgaard, Sarah K. Gersing, Sven Larsen-Ledet, Sofie V. Nielsen, Amelie Stein, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Published 2020-08-01

The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins.

by Louise Madsen, Franziska Kriegenburg, Andrea Vala, Diana Best, Søren Prag, Kay Hofmann, Michael Seeger, Ian R Adams, Rasmus Hartmann-Petersen
Published 2011-01-01

A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability.

by Franziska Kriegenburg, Visnja Jakopec, Esben G Poulsen, Sofie Vincents Nielsen, Assen Roguev, Nevan Krogan, Colin Gordon, Ursula Fleig, Rasmus Hartmann-Petersen
Published 2014-01-01

Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing.

by Irina N Marinova, Jacob Engelbrecht, Adrian Ewald, Lasse L Langholm, Christian Holmberg, Birthe B Kragelund, Colin Gordon, Olaf Nielsen, Rasmus Hartmann-Petersen
Published 2015-01-01

Expanded Interactome of the Intrinsically Disordered Protein Dss1

by Signe M. Schenstrøm, Caio A. Rebula, Michael H. Tatham, Ruth Hendus-Altenburger, Isabelle Jourdain, Ronald T. Hay, Birthe B. Kragelund, Rasmus Hartmann-Petersen
Published 2018-10-01

Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the Pap1 transcription factor.

by Mary Penney, Itaru Samejima, Caroline R Wilkinson, Christopher J McInerny, Søs G Mathiassen, Mairi Wallace, Takashi Toda, Rasmus Hartmann-Petersen, Colin Gordon
Published 2012-01-01

Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation.

by Lene Clausen, Amelie Stein, Martin Grønbæk-Thygesen, Lasse Nygaard, Cecilie L Søltoft, Sofie V Nielsen, Michael Lisby, Tommer Ravid, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Published 2020-11-01

Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations.

by Sofie V Nielsen, Amelie Stein, Alexander B Dinitzen, Elena Papaleo, Michael H Tatham, Esben G Poulsen, Maher M Kassem, Lene J Rasmussen, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Published 2017-04-01

Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

by Amanda B Abildgaard, Amelie Stein, Sofie V Nielsen, Katrine Schultz-Knudsen, Elena Papaleo, Amruta Shrikhande, Eva R Hoffmann, Inge Bernstein, Anne-Marie Gerdes, Masanobu Takahashi, Chikashi Ishioka, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Published 2019-11-01