A Live-Attenuated Prime, Inactivated Boost Vaccination Strategy with Chimeric Hemagglutinin-Based Universal Influenza Virus Vaccines Provides Protection in Ferrets: A Confirmatory...

by Raffael Nachbagauer, Florian Krammer, Randy A. Albrecht
Published 2018-07-01

Age Dependence and Isotype Specificity of Influenza Virus Hemagglutinin Stalk-Reactive Antibodies in Humans

by Raffael Nachbagauer, Angela Choi, Ruvim Izikson, Manon M. Cox, Peter Palese, Florian Krammer
Published 2016-01-01

A Cross-Reactive Mouse Monoclonal Antibody against Rhinovirus Mediates Phagocytosis In Vitro

by Mohammad Amin Behzadi, James Duehr, Angela Choi, Michael Schotsaert, Adolfo García-Sastre, Peter Palese, Raffael Nachbagauer
Published 2020-07-01

An Influenza Virus Hemagglutinin-Based Vaccine Platform Enables the Generation of Epitope Specific Human Cytomegalovirus Antibodies

by Mohammad Amin Behzadi, Kathryn R. Stein, Maria Carolina Bermúdez-González, Viviana Simon, Raffael Nachbagauer, Domenico Tortorella
Published 2019-06-01

An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations.

by Madhusudan Rajendran, Weina Sun, Phillip Comella, Raffael Nachbagauer, Teddy John Wohlbold, Fatima Amanat, Ericka Kirkpatrick, Peter Palese, Florian Krammer
Published 2018-01-01

Globular Head-Displayed Conserved Influenza H1 Hemagglutinin Stalk Epitopes Confer Protection against Heterologous H1N1 Virus.

by Miriam Klausberger, Rupert Tscheliessnig, Silke Neff, Raffael Nachbagauer, Teddy John Wohlbold, Monika Wilde, Dieter Palmberger, Florian Krammer, Alois Jungbauer, Reingard Grabherr
Published 2016-01-01

Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model

by Henning Jacobsen, Madhusudan Rajendran, Angela Choi, Haakon Sjursen, Karl A. Brokstad, Rebecca J. Cox, Peter Palese, Florian Krammer, Raffael Nachbagauer, Rino Rappuoli
Published 2017-09-01

Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner

by Caitlin E. Mullarkey, Mark J. Bailey, Diana A. Golubeva, Gene S. Tan, Raffael Nachbagauer, Wenqian He, Kyle E. Novakowski, Dawn M. Bowdish, Matthew S. Miller, Peter Palese
Published 2016-10-01

Vaccination with a Recombinant H7 Hemagglutinin-Based Influenza Virus Vaccine Induces Broadly Reactive Antibodies in Humans

by Daniel Stadlbauer, Arvind Rajabhathor, Fatima Amanat, Daniel Kaplan, Abusaleh Masud, John J. Treanor, Ruvim Izikson, Manon M. Cox, Raffael Nachbagauer, Florian Krammer, Marcela F. Pasetti
Published 2017-12-01

Targeting Antigen to the Surface of EVs Improves the In Vivo Immunogenicity of Human and Non-human Adenoviral Vaccines in Mice

by Carly M. Bliss, Andrea J. Parsons, Raffael Nachbagauer, Jennifer R. Hamilton, Federica Cappuccini, Marta Ulaszewska, Jason P. Webber, Aled Clayton, Adrian V.S. Hill, Lynda Coughlan
Published 2020-03-01

Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin

by Madhusudan Rajendran, Raffael Nachbagauer, Megan E. Ermler, Paul Bunduc, Fatima Amanat, Ruvim Izikson, Manon Cox, Peter Palese, Maryna Eichelberger, Florian Krammer, Joseph Bresee, Keith P. Klugman
Published 2017-03-01

Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate

by Erin E. H. Tran, Kira A. Podolsky, Alberto Bartesaghi, Oleg Kuybeda, Giovanna Grandinetti, Teddy John Wohlbold, Gene S. Tan, Raffael Nachbagauer, Peter Palese, Florian Krammer, Sriram Subramaniam
Published 2016-03-01

Influenza Virus Infection Induces a Narrow Antibody Response in Children but a Broad Recall Response in Adults

by Philip Meade, Guillermina Kuan, Shirin Strohmeier, Hannah E. Maier, Fatima Amanat, Angel Balmaseda, Kimihito Ito, Ericka Kirkpatrick, Andres Javier, Lionel Gresh, Raffael Nachbagauer, Aubree Gordon, Florian Krammer
Published 2020-01-01

Chimeric Hemagglutinin-Based Live-Attenuated Vaccines Confer Durable Protective Immunity against Influenza A Viruses in a Preclinical Ferret Model

by Wen-Chun Liu, Raffael Nachbagauer, Daniel Stadlbauer, Shirin Strohmeier, Alicia Solórzano, Francesco Berlanda-Scorza, Bruce L. Innis, Adolfo García-Sastre, Peter Palese, Florian Krammer, Randy A. Albrecht
Published 2021-01-01

Antigen modifications improve nucleoside-modified mRNA-based influenza virus vaccines in mice

by Alec W. Freyn, Matthew Pine, Victoria C. Rosado, Marcel Benz, Hiromi Muramatsu, Mitchell Beattie, Ying K. Tam, Florian Krammer, Peter Palese, Raffael Nachbagauer, Meagan McMahon, Norbert Pardi
Published 2021-09-01

A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies

by Sun-Young Sunwoo, Michael Schotsaert, Igor Morozov, Anne Sally Davis, Yuhao Li, Jinhwa Lee, Chester McDowell, Philip Meade, Raffael Nachbagauer, Adolfo García-Sastre, Wenjun Ma, Florian Krammer, Juergen A. Richt
Published 2018-09-01

Erratum: Sunwoo, S.-Y. et al. A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies. <em>Vaccines</em> 20...

by Sun-Young Sunwoo, Michael Schotsaert, Igor Morozov, Anne Sally Davis, Yuhao Li, Jinhwa Lee, Chester McDowell, Philip Meade, Raffael Nachbagauer, Adolfo García-Sastre, Wenjun Ma, Florian Krammer, Juergen A. Richt
Published 2018-11-01

AS03-adjuvanted H7N9 inactivated split virion vaccines induce cross-reactive and protective responses in ferrets

by Daniel Stadlbauer, Leon de Waal, Edith Beaulieu, Shirin Strohmeier, Edwin J. B. Veldhuis Kroeze, Philippe Boutet, Albert D. M. E. Osterhaus, Florian Krammer, Bruce L. Innis, Raffael Nachbagauer, Koert J. Stittelaar, Corey P. Mallett
Published 2021-03-01

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model

by Wen-Chun Liu, Wen-Chun Liu, Raffael Nachbagauer, Daniel Stadlbauer, Alicia Solórzano, Francesco Berlanda-Scorza, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Peter Palese, Peter Palese, Florian Krammer, Randy A. Albrecht, Randy A. Albrecht
Published 2019-04-01

Viral Fitness Landscapes in Diverse Host Species Reveal Multiple Evolutionary Lines for the NS1 Gene of Influenza A Viruses

by Raquel Muñoz-Moreno, Carles Martínez-Romero, Daniel Blanco-Melo, Christian V. Forst, Raffael Nachbagauer, Asiel Arturo Benitez, Ignacio Mena, Sadaf Aslam, Vinod Balasubramaniam, Ilseob Lee, Maryline Panis, Juan Ayllón, David Sachs, Man-Seong Park, Florian Krammer, Benjamin R. tenOever, Adolfo García-Sastre
Published 2019-12-01