Carbinolamine formation and dehydration in a DNA repair enzyme active site.

by M L Dodson, Ross C Walker, R Stephen Lloyd
Published 2012-01-01

Inhibition of HIV-1 reverse transcriptase-catalyzed synthesis by intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide adducts.

by Parvathi Chary, William A Beard, Samuel H Wilson, R Stephen Lloyd
Published 2013-01-01

8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction.

by Harini Sampath, Vladimir Vartanian, M Rick Rollins, Kunihiko Sakumi, Yusaku Nakabeppu, R Stephen Lloyd
Published 2012-01-01

Maternal Transmission of Human OGG1 Protects Mice Against Genetically- and Diet-Induced Obesity Through Increased Tissue Mitochondrial Content

by Natalie Burchat, Priyanka Sharma, Hong Ye, Sai Santosh Babu Komakula, Sai Santosh Babu Komakula, Agnieszka Dobrzyn, Agnieszka Dobrzyn, Vladimir Vartanian, R. Stephen Lloyd, R. Stephen Lloyd, Harini Sampath, Harini Sampath, Harini Sampath
Published 2021-09-01

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle.

by Vladimir Vartanian, Jana Tumova, Pawel Dobrzyn, Agnieszka Dobrzyn, Yusaku Nakabeppu, R Stephen Lloyd, Harini Sampath
Published 2017-01-01

OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model.

by Holly Simon, Vladimir Vartanian, Melissa H Wong, Yusaku Nakabeppu, Priyanka Sharma, R Stephen Lloyd, Harini Sampath
Published 2020-01-01

A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.

by Kinrin Yamanaka, Dorjbal Dorjsuren, Robert L Eoff, Martin Egli, David J Maloney, Ajit Jadhav, Anton Simeonov, R Stephen Lloyd
Published 2012-01-01

The base excision repair pathway is required for efficient lentivirus integration.

by Kristine E Yoder, Amy Espeseth, Xiao-hong Wang, Qingming Fang, Maria Teresa Russo, R Stephen Lloyd, Daria Hazuda, Robert W Sobol, Richard Fishel
Published 2011-03-01

Inhibition of DNA glycosylases via small molecule purine analogs.

by Aaron C Jacobs, Marcus J Calkins, Ajit Jadhav, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Miral Dizdaroglu, Amanda K McCullough, R Stephen Lloyd
Published 2013-01-01