EZH2-Mediated Inactivation of IFN-γ-JAK-STAT1 Signaling Is an Effective Therapeutic Target in MYC-Driven Prostate Cancer

by Zhen Ning Wee, Zhimei Li, Puay Leng Lee, Shuet Theng Lee, Yoon Pin Lim, Qiang Yu
Published 2014-07-01

Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML).

by Xia Jiang, Cheryl Zi Hui Lim, Zhimei Li, Puay Leng Lee, Siti Maryam J M Yatim, Peiyong Guan, Juntao Li, Jianbiao Zhou, Jingxuan Pan, Wee-Joo Chng, Christina L L Chai, Qiang Yu
Published 2015-01-01

EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy

by Yi Bao, Gokce Oguz, Wee Chyan Lee, Puay Leng Lee, Kakaly Ghosh, Jiayao Li, Panpan Wang, Peter E. Lobie, Sidse Ehmsen, Henrik J. Ditzel, Andrea Wong, Ern Yu Tan, Soo Chin Lee, Qiang Yu
Published 2020-11-01

Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer

by Wenyu Wang, Yen-An Tang, Qian Xiao, Wee Chyan Lee, Bing Cheng, Zhitong Niu, Gokce Oguz, Min Feng, Puay Leng Lee, Baojie Li, Zi-huan Yang, Yu-feng Chen, Ping Lan, Xiao-Jian Wu, Qiang Yu
Published 2021-07-01