Exploring Heterocycle-Spermine Conjugates as Modulators of Oncogenic microRNAs Biogenesis

by Cécile Becquart, Myriame Le Roch, Stéphane Azoulay, Philippe Uriac, Audrey Di Giorgio, Maria Duca
Published 2018-12-01

Combined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight Chagas' disease.

by Armand Berneman, Lory Montout, Sophie Goyard, Nathalie Chamond, Alain Cosson, Simon d'Archivio, Nicolas Gouault, Philippe Uriac, Arnaud Blondel, Paola Minoprio
Published 2013-01-01

Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography.

by Patricia de Aguiar Amaral, Delphine Autheman, Guilherme Dias de Melo, Nicolas Gouault, Jean-François Cupif, Sophie Goyard, Patricia Dutra, Nicolas Coatnoan, Alain Cosson, Damien Monet, Frederick Saul, Ahmed Haouz, Philippe Uriac, Arnaud Blondel, Paola Minoprio
Published 2018-10-01