How Does the L884P Mutation Confer Resistance to Type-II Inhibitors of JAK2 Kinase: A Comprehensive Molecular Modeling Study

by Xiaotian Kong, Huiyong Sun, Peichen Pan, Dan Li, Feng Zhu, Shan Chang, Lei Xu, Youyong Li, Tingjun Hou
Published 2017-08-01

Comparative analyses of structural features and scaffold diversity for purchasable compound libraries

by Jun Shang, Huiyong Sun, Hui Liu, Fu Chen, Sheng Tian, Peichen Pan, Dan Li, Dexin Kong, Tingjun Hou
Published 2017-04-01

Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes

by Qing Yu, Zhiguo Hu, Yanwen Shen, Yihan Jiang, Peichen Pan, Tingjun Hou, Zhen-Qiang Pan, Jing Huang, Yi Sun
Published 2020-04-01

Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type‑I1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation

by Peichen Pan, Huidong Yu, Qinglan Liu, Xiaotian Kong, Hu Chen, Jiean Chen, Qi Liu, Dan Li, Yu Kang, Huiyong Sun, Wenfang Zhou, Sheng Tian, Sunliang Cui, Feng Zhu, Youyong Li, Yong Huang, Tingjun Hou
Published 2017-11-01