Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events

by Cristina Carvalho, Cristina Carvalho, Paula I. Moreira, Paula I. Moreira
Published 2018-07-01

Insulin in Central Nervous System: More than Just a Peripheral Hormone

by Ana I. Duarte, Paula I. Moreira, Catarina R. Oliveira
Published 2012-01-01

Glycogen Synthase Kinase 3: A Point of Integration in Alzheimer's Disease and a Therapeutic Target?

by Siddhartha Mondragón-Rodríguez, George Perry, Xiongwei Zhu, Paula I. Moreira, Sylvain Williams
Published 2012-01-01

Insulin protects against amyloid β-peptide toxicity in brain mitochondria of diabetic rats

by Paula I. Moreira, Maria S. Santos, Cristina Sena, Raquel Seiça, Catarina R. Oliveira
Published 2005-04-01

Insulin as a bridge between type 2 diabetes and Alzheimer disease – How anti-diabetics could be a solution for dementia

by Inês eSebastião, Inês eSebastião, Inês eSebastião, Emanuel eCandeias, Emanuel eCandeias, Maria S Santos, Maria S Santos, Maria S Santos, Catarina R. Oliveira, Catarina R. Oliveira, Catarina R. Oliveira, Paula I Moreira, Paula I Moreira, Paula I Moreira, Ana I Duarte, Ana I Duarte
Published 2014-07-01

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

by Peter M. J. Quinn, Paula I. Moreira, António Francisco Ambrósio, C. Henrique Alves
Published 2020-11-01

IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis

by Susana Cardoso, Icíar P. López, Sergio Piñeiro-Hermida, José G. Pichel, Paula I. Moreira
Published 2021-02-01

Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer’s Disease

by Sónia C. Correia, Nuno J. Machado, Marco G. Alves, Pedro F. Oliveira, Paula I. Moreira
Published 2021-01-01

Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer’s Disease

by Siddhartha Mondragón-Rodríguez, George Perry, Xiongwei Zhu, Paula I. Moreira, Mariana C. Acevedo-Aquino, Sylvain Williams
Published 2013-01-01

Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1α

by Sónia C. Correia, Renato X. Santos, Sandra M. Cardoso, Maria S. Santos, Catarina R. Oliveira, Paula I. Moreira
Published 2012-01-01

Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease

by Mark A. Smith, George Perry, Atsushi Takeda, Paula I. Moreira, Raj K. Rolston, Akihiko Nunomura, Rudy J. Castellani
Published 2008-05-01

Mitochondrial preconditioning: a potential neuroprotective strategy

by Sónia C Correia, Sónia C Correia, Cristina Carvalho, Cristina Carvalho, Susana Cardoso, Susana Cardoso, Renato X Santos, Renato X Santos, Maria S Santos, Maria S Santos, Catarina Oliveira, Catarina Oliveira, George Perry, George Perry, Xiongwei Zhu, Mark A Smith, Paula I Moreira, Paula I Moreira
Published 2010-08-01

Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study

by Samuel Chiquita, Elisa J. Campos, João Castelhano, Mário Ribeiro, José Sereno, Paula I. Moreira, Miguel Castelo-Branco, António Francisco Ambrósio
Published 2019-11-01

Compensatory responses induced by oxidative stress in Alzheimer disease

by PAULA I MOREIRA, XIONGWEI ZHU, QUAN LIU, KAZUHIRO HONDA, SANDRA L SIEDLAK, PEGGY L HARRIS, MARK A. SMITH, GEORGE PERRY
Published 2006-01-01

Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance

by Susana Cardoso, Renato X. Santos, Sónia C. Correia, Cristina Carvalho, Maria S. Santos, Inês Baldeiras, Catarina R. Oliveira, Paula I. Moreira
Published 2013-01-01

Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets

by Paula I. Moreira, Gemma Casadesus, Mark A. Smith, George Perry, Hyoung-Gon Lee, Cristina Carvalho, Xiongwei Zhu, Sonia Correia, Susana Cardoso, Renato Santos
Published 2009-12-01

Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors

by Judite R. M. Coimbra, Salete J. Baptista, Teresa C. P. Dinis, Maria M. C. Silva, Paula I. Moreira, Armanda E. Santos, Jorge A. R. Salvador
Published 2020-04-01

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Diseas...

by Tânia Fernandes, Rosa Resende, Diana F. Silva, Ana P. Marques, Armanda E. Santos, Sandra M. Cardoso, M. Rosário Domingues, Paula I. Moreira, Cláudia F. Pereira
Published 2021-07-01

Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort

by Bianca Gerardo, Marina Cabral Pinto, Joana Nogueira, Paula Pinto, Agostinho Almeida, Edgar Pinto, Paula Marinho-Reis, Luísa Diniz, Paula I. Moreira, Mário R. Simões, Sandra Freitas
Published 2020-08-01

Liraglutide Protects Against Brain Amyloid-β_1–42 Accumulation in Female Mice with Early Alzheimer’s Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative St...

by Ana I. Duarte, Emanuel Candeias, Inês N. Alves, Débora Mena, Daniela F. Silva, Nuno J. Machado, Elisa J. Campos, Maria S. Santos, Catarina R. Oliveira, Paula I. Moreira
Published 2020-03-01