What Has the Study of the K3 and K5 Viral Ubiquitin E3 Ligases Taught Us about Ubiquitin-Mediated Receptor Regulation?

by Paul J. Lehner, Jessica M. Boname
Published 2011-01-01

Antibody-free magnetic cell sorting of genetically modified primary human CD4+ T cells by one-step streptavidin affinity purification.

by Nicholas J Matheson, Andrew A Peden, Paul J Lehner
Published 2014-01-01

A 58-year-old woman with abdominal symptoms and elevated C-reactive protein.

by Marie-Louise Daly, David J Cartwright, Paul J Lehner, Babak Javid
Published 2008-07-01

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

by Richard T. Timms, Iva A. Tchasovnikarova, Robin Antrobus, Gordon Dougan, Paul J. Lehner
Published 2016-10-01

A genome-wide CRISPR screen identifies regulation factors of the TLR3 signalling pathway

by Laurent Zablocki-Thomas, Sam A Menzies, Paul J Lehner, Nicolas Manel, Philippe Benaroch
Published 2020-08-01

Functional proteomic atlas of HIV infection in primary human CD4+ T cells

by Adi Naamati, James C Williamson, Edward JD Greenwood, Sara Marelli, Paul J Lehner, Nicholas J Matheson
Published 2019-03-01

No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor

by Jarrod Shilts, Thomas W. M. Crozier, Edward J. D. Greenwood, Paul J. Lehner, Gavin J. Wright
Published 2021-01-01

Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells.

by Lidia M Duncan, Richard T Timms, Eszter Zavodszky, Florencia Cano, Gordon Dougan, Felix Randow, Paul J Lehner
Published 2012-01-01

Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection

by Edward J.D. Greenwood, James C. Williamson, Agata Sienkiewicz, Adi Naamati, Nicholas J. Matheson, Paul J. Lehner
Published 2019-04-01

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

by Christopher H. Douse, Stuart Bloor, Yangci Liu, Maria Shamin, Iva A. Tchasovnikarova, Richard T. Timms, Paul J. Lehner, Yorgo Modis
Published 2018-02-01

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

by Sam A Menzies, Norbert Volkmar, Dick JH van den Boomen, Richard T Timms, Anna S Dickson, James A Nathan, Paul J Lehner
Published 2018-12-01

Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants

by Edward JD Greenwood, Nicholas J Matheson, Kim Wals, Dick JH van den Boomen, Robin Antrobus, James C Williamson, Paul J Lehner
Published 2016-09-01

Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases.

by Richard T Timms, Lidia M Duncan, Iva A Tchasovnikarova, Robin Antrobus, Duncan L Smith, Gordon Dougan, Michael P Weekes, Paul J Lehner
Published 2013-01-01

CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.

by Ondrej Cerny, Camilla Godlee, Romina Tocci, Nancy E Cross, Haoran Shi, James C Williamson, Eric Alix, Paul J Lehner, David W Holden
Published 2021-07-01

Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

by Sara Marelli, James C Williamson, Anna V Protasio, Adi Naamati, Edward JD Greenwood, Janet E Deane, Paul J Lehner, Nicholas J Matheson
Published 2020-04-01

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

by Richard T. Timms, Sam A. Menzies, Iva A. Tchasovnikarova, Lea C. Christensen, James C. Williamson, Robin Antrobus, Gordon Dougan, Lars Ellgaard, Paul J. Lehner
Published 2016-06-01

Interferon-Responsive Genes Are Targeted during the Establishment of Human Cytomegalovirus Latency

by Elizabeth G. Elder, Benjamin A. Krishna, James Williamson, Eleanor Y. Lim, Emma Poole, George X. Sedikides, Mark Wills, Christine M. O’Connor, Paul J. Lehner, John Sinclair
Published 2019-12-01

Monocytes Latently Infected with Human Cytomegalovirus Evade Neutrophil Killing

by Elizabeth Elder, Benjamin Krishna, James Williamson, Yusuf Aslam, Neda Farahi, Alexander Wood, Veronika Romashova, Kate Roche, Eain Murphy, Edwin Chilvers, Paul J. Lehner, John Sinclair, Emma Poole
Published 2019-02-01

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

by Dick J. H. van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke L. M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques J. C. Neefjes, Paul J. Lehner
Published 2020-11-01

Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters

by David A. Rhodes, Hung-Chang Chen, James C. Williamson, Alfred Hill, Jack Yuan, Sam Smith, Harriet Rhodes, John Trowsdale, Paul J. Lehner, Thomas Herrmann, Matthias Eberl, Matthias Eberl
Published 2018-04-01