If Virchow and Ehrlich Had Dreamt Together: What the Future Holds for <i>KRAS</i>-Mutant Lung Cancer

by Jens Köhler, Pasi A. Jänne
Published 2021-03-01

Molecular mechanisms of resistance in epidermal growth factor receptor-mutant lung adenocarcinomas

by Alexis B. Cortot, Pasi A. Jänne
Published 2014-09-01

An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancerResearch in context

by Haiyun Wang, Qi Lv, Yue Xu, Zhaoqing Cai, Jie Zheng, Xiaojie Cheng, Yao Dai, Pasi A. Jänne, Chiara Ambrogio, Jens Köhler
Published 2019-11-01

Plasma IL-6 changes correlate to PD-1 inhibitor responses in NSCLC

by Alissa Keegan, Padric Garden, Limor Cohen, Reiko Nishihara, Anika Adeni, Cloud Paweletz, Julianna Supplee, Pasi A Jänne, Mark M Awad, David R Walt
Published 2020-07-01

Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.

by Heidi Greulich, Tzu-Hsiu Chen, Whei Feng, Pasi A Jänne, James V Alvarez, Mauro Zappaterra, Sara E Bulmer, David A Frank, William C Hahn, William R Sellers, Matthew Meyerson
Published 2005-11-01

Rapamycin Prevents the Development and Progression of Mutant Epidermal Growth Factor Receptor Lung Tumors with the Acquired Resistance Mutation T790M

by Shigeru Kawabata, José R. Mercado-Matos, M. Christine Hollander, Danielle Donahue, Willie Wilson III, Lucia Regales, Mohit Butaney, William Pao, Kwok-Kin Wong, Pasi A. Jänne, Phillip A. Dennis
Published 2014-06-01

Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease.

by Luca Toschi, Giovanna Finocchiaro, Teresa T Nguyen, Margaret C Skokan, Laura Giordano, Letizia Gianoncelli, Matteo Perrino, Licia Siracusano, Luca Di Tommaso, Maurizio Infante, Marco Alloisio, Massimo Roncalli, Marta Scorsetti, Pasi A Jänne, Armando Santoro, Marileila Varella-Garcia
Published 2014-01-01

Genomic and pathological heterogeneity in clinically diagnosed small cell lung cancer in never/light smokers identifies therapeutically targetable alterations

by Atsuko Ogino, Jihyun Choi, Mika Lin, Margaret K. Wilkens, Antonio Calles, Man Xu, Anika E. Adeni, Emily S. Chambers, Marzia Capelletti, Mohit Butaney, Nathanael S. Gray, Prafulla C. Gokhale, Sangeetha Palakurthi, Paul Kirschmeier, Geoffrey R. Oxnard, Lynette M. Sholl, Pasi A. Jänne
Published 2021-01-01

Efficacy of Taletrectinib (AB-106/DS-6051b) in ROS1+ NSCLC: An Updated Pooled Analysis of U.S. and Japan Phase 1 Studies

by Sai-Hong Ignatius Ou, MD, PhD, Yutaka Fujiwara, MD, PhD, Alice T. Shaw, MD, PhD, Noboru Yamamoto, MD, PhD, Kazuhiko Nakagawa, MD, PhD, Frank Fan, MD, Yuki Hao, MSc, Yanfei Gao, MSc, Pasi A. Jänne, MD, Takashi Seto, MD
Published 2021-01-01

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

by Elsa B Krall, Belinda Wang, Diana M Munoz, Nina Ilic, Srivatsan Raghavan, Matthew J Niederst, Kristine Yu, David A Ruddy, Andrew J Aguirre, Jong Wook Kim, Amanda J Redig, Justin F Gainor, Juliet A Williams, John M Asara, John G Doench, Pasi A Janne, Alice T Shaw, Robert E McDonald III, Jeffrey A Engelman, Frank Stegmeier, Michael R Schlabach, William C Hahn
Published 2017-02-01

Correction: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

by Elsa Beyer Krall, Belinda Wang, Diana M Munoz, Nina Ilic, Srivatsan Raghavan, Matthew J Niederst, Kristine Yu, David A Ruddy, Andrew J Aguirre, Jong Wook Kim, Amanda J Redig, Justin F Gainor, Juliet A Williams, John M Asara, John G Doench, Pasi A Janne, Alice T Shaw, Robert E McDonald III III, Jeffrey A Engelman, Frank Stegmeier, Michael R Schlabach, William C Hahn
Published 2017-10-01

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

by Shohei Koyama, Esra A. Akbay, Yvonne Y. Li, Grit S. Herter-Sprie, Kevin A. Buczkowski, William G. Richards, Leena Gandhi, Amanda J. Redig, Scott J. Rodig, Hajime Asahina, Robert E. Jones, Meghana M. Kulkarni, Mari Kuraguchi, Sangeetha Palakurthi, Peter E. Fecci, Bruce E. Johnson, Pasi A. Janne, Jeffrey A. Engelman, Sidharta P. Gangadharan, Daniel B. Costa, Gordon J. Freeman, Raphael Bueno, F. Stephen Hodi, Glenn Dranoff, Kwok-Kin Wong, Peter S. Hammerman
Published 2016-02-01