3C-like proteinase, SARS-CoV-2 Antiviral Agents Article COVID-19 Cannabidiol Cannabinoids Cannabinols Computer Simulation Coronavirus 3C Proteases Dronabinol Drug Evaluation, Preclinical Humans IC50 In Vitro Techniques In vitro antiviral assay Ligands Models, Biological Molecular Docking Simulation Molecular Dynamics Simulation Pandemics Protease Inhibitors SARS-CoV-2 SARS-CoV-2 and Mpro enzyme Severe acute respiratory syndrome coronavirus 2 Vero cell line animal cell antiviral activity antivirus agent binding affinity binding site