3' untranslated region ALOX12 ALOX12 protein AML12 cell line Acetaminophen-induced liver injury Article DNA microarray FTH1 gene G protein coupled receptor G protein coupled receptor alpha 12 GPX4 GPX4 gene Gna12 gene Gα12 HMGB1 gene MiR-15a RNA analysis RNA sequencing Rho kinase Rho kinase 1 X box binding protein 1 animal cell animal experiment animal model animal tissue binding site complementary DNA controlled study disease association disease severity