Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction

by Paganetti Paolo, Roscic Ana, Weiss Andreas
Published 2009-02-01

The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of...

by Frentzel Stefan, Hoyer Daniel, Betschart Claudia, Bleckmann Dorothee, Kama Jibrin A, Dorsey Kate, Chopra Vanita, Connor Teal, Fox Jonathan H, DiFiglia Marian, Paganetti Paolo, Hersch Steven M
Published 2010-06-01

Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors

by Betschart Claudia, Kuhn Rainer, Curtis Daniel, Palacino James, Krainc Dimitri, Jeong Hyunkyung, Valencia Antonio, Masso Nicholas, Sobin Linsday, Bleckmann Dorothee, Reeves Patrick, Alexander Jonathan, Sapp Ellen, Kegel Kimberly B, Sena-Esteves Miguel, Aronin Neil, Paganetti Paolo, DiFiglia Marian
Published 2010-12-01