p21-Activated Kinase 1 Is Permissive for the Skeletal Muscle Hypertrophy Induced by Myostatin Inhibition

by Caroline Barbé, Audrey Loumaye, Pascale Lause, Olli Ritvos, Jean-Paul Thissen
Published 2021-06-01

Differentiation of Murine C2C12 Myoblasts Strongly Reduces the Effects of Myostatin on Intracellular Signaling

by Juulia H. Lautaoja, Satu Pekkala, Arja Pasternack, Mika Laitinen, Olli Ritvos, Juha J. Hulmi
Published 2020-04-01

Soluble activin type IIB receptor improves fracture healing in a closed tibial fracture mouse model.

by Tero Puolakkainen, Petri Rummukainen, Jemina Lehto, Olli Ritvos, Ari Hiltunen, Anna-Marja Säämänen, Riku Kiviranta
Published 2017-01-01

Blocking Activin Receptor Ligands Is Not Sufficient to Rescue Cancer-Associated Gut Microbiota—A Role for Gut Microbial Flagellin in Colorectal Cancer and Cachexia?

by Satu Pekkala, Anniina Keskitalo, Emilia Kettunen, Sanna Lensu, Noora Nykänen, Teijo Kuopio, Olli Ritvos, Jaakko Hentilä, Tuuli A. Nissinen, Juha J. Hulmi
Published 2019-11-01

Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses

by Tuuli A. Nissinen, Jaakko Hentilä, Fabio Penna, Anita Lampinen, Juulia H. Lautaoja, Vasco Fachada, Tanja Holopainen, Olli Ritvos, Riikka Kivelä, Juha J. Hulmi
Published 2018-06-01

Activin Receptor Ligand Blocking and Cancer Have Distinct Effects on Protein and Redox Homeostasis in Skeletal Muscle and Liver

by Jaakko Hentilä, Tuuli A. Nissinen, Ayhan Korkmaz, Sanna Lensu, Mika Silvennoinen, Arja Pasternack, Olli Ritvos, Mustafa Atalay, Juha J. Hulmi, Juha J. Hulmi
Published 2019-01-01

Prevention of chemotherapy‐induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle

by Juha J. Hulmi, Tuuli A. Nissinen, Markus Räsänen, Joni Degerman, Juulia H. Lautaoja, Karthik Amudhala Hemanthakumar, Janne T. Backman, Olli Ritvos, Mika Silvennoinen, Riikka Kivelä
Published 2018-04-01

A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities

by Danielle Vaughan, Robert Mitchell, Oliver Kretz, David Chambers, Maciej Lalowski, Helge Amthor, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Sakthivel Vaiyapuri, Tobias B. Huber, Bernd Denecke, Abir Mukherjee, Darius Widera, Ketan Patel
Published 2021-02-01

Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development

by Danielle Vaughan, Olli Ritvos, Robert Mitchell, Oliver Kretz, Maciej Lalowski, Helge Amthor, David Chambers, Antonios Matsakas, Arja Pasternack, Henry Collins-Hooper, Randy Ballesteros, Tobias B. Huber, Bernd Denecke, Darius Widera, Abir Mukherjee, Ketan Patel
Published 2020-01-01

Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention

by Danielle Vaughan, Oliver Kretz, Ali Alqallaf, Robert Mitchell, Jennie L. von der Heide, Sakthivel Vaiyapuri, Antonios Matsakas, Arja Pasternack, Henry Collins-Hooper, Olli Ritvos, Randy Ballesteros, Tobias B. Huber, Helge Amthor, Abir Mukherjee, Ketan Patel
Published 2020-06-01

Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres

by Saleh Omairi, Antonios Matsakas, Hans Degens, Oliver Kretz, Kenth-Arne Hansson, Andreas Våvang Solbrå, Jo C Bruusgaard, Barbara Joch, Roberta Sartori, Natasa Giallourou, Robert Mitchell, Henry Collins-Hooper, Keith Foster, Arja Pasternack, Olli Ritvos, Marco Sandri, Vihang Narkar, Jonathan R Swann, Tobias B Huber, Ketan Patel
Published 2016-08-01

Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

by Khalid Alyodawi, Wilbert P. Vermeij, Saleh Omairi, Oliver Kretz, Mark Hopkinson, Francesca Solagna, Barbara Joch, Renata M.C. Brandt, Sander Barnhoorn, Nicole vanVliet, Yanto Ridwan, Jeroen Essers, Robert Mitchell, Taryn Morash, Arja Pasternack, Olli Ritvos, Antonios Matsakas, Henry Collins‐Hooper, Tobias B. Huber, Jan H.J. Hoeijmakers, Ketan Patel
Published 2019-06-01

COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants

by Pinja Jalkanen, Pekka Kolehmainen, Hanni K. Häkkinen, Moona Huttunen, Paula A. Tähtinen, Rickard Lundberg, Sari Maljanen, Arttu Reinholm, Sisko Tauriainen, Sari H. Pakkanen, Iris Levonen, Arttu Nousiainen, Taru Miller, Hanna Välimaa, Lauri Ivaska, Arja Pasternack, Rauno Naves, Olli Ritvos, Pamela Österlund, Suvi Kuivanen, Teemu Smura, Jussi Hepojoki, Olli Vapalahti, Johanna Lempainen, Laura Kakkola, Anu Kantele, Ilkka Julkunen
Published 2021-06-01

Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue

by Anastasia Georgiadi, Valeria Lopez-Salazar, Rabih El- Merahbi, Rhoda Anane Karikari, Xiaochuan Ma, André Mourão, Katarina Klepac, Lea Bühler, Ana Jimena Alfaro, Isabell Kaczmarek, Adam Linford, Madeleen Bosma, Olga Shilkova, Olli Ritvos, Nobuhiro Nakamura, Shigehisa Hirose, Maximilian Lassi, Raffaele Teperino, Juliano Machado, Marcel Scheideler, Arne Dietrich, Arie Geerlof, Annette Feuchtinger, Andreas Blutke, Katrin Fischer, Timo Dirk Müller, Katharina Kessler, Torsten Schöneberg, Doreen Thor, Silke Hornemann, Michael Kruse, Peter Nawroth, Olga Pivovarova-Ramich, Andreas Friedrich Hermann Pfeiffer, Michael Sattler, Matthias Blüher, Stephan Herzig
Published 2021-05-01