Inflammatory Bowel Disease: Are There Gender Differences in the Genetics of Signal Transduction? A Preliminary Study of Cytosolic Low Molecular Weight Protein Tyrosine Phosphatase

by Nunzio Bottini, Fulvia Gloria-Bottini, Nazzareno Lucarini, Pier Giulio Ronchetti, Luigi Fontana
Published 2000-01-01

PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis

by Wan-Chen Hsieh, Mattias N.D. Svensson, Martina Zoccheddu, Michael L. Tremblay, Shimon Sakaguchi, Stephanie M. Stanford, Nunzio Bottini
Published 2020-10-01

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

by Meng Zhao, Mattias N. D. Svensson, Koen Venken, Ashu Chawla, Shu Liang, Isaac Engel, Piotr Mydel, Jeremy Day, Dirk Elewaut, Nunzio Bottini, Mitchell Kronenberg
Published 2018-07-01

Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity

by Peter Szodoray, Tor Kristian Andersen, Julia Heinzelbecker, John F. Imbery, Peter C. Huszthy, Stephanie M. Stanford, Bjarne Bogen, Ole B. Landsverk, Nunzio Bottini, Anders Tveita, Ludvig A. Munthe, Britt Nakken
Published 2021-08-01

Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.

by Dennis J Wu, Wenbo Zhou, Sarah Enouz, Valeria Orrú, Stephanie M Stanford, Christian J Maine, Novella Rapini, Kristy Sawatzke, Isaac Engel, Edoardo Fiorillo, Linda A Sherman, Mitch Kronenberg, Dietmar Zehn, Erik Peterson, Nunzio Bottini
Published 2014-01-01

CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells

by Jae-Ho Cho, Hee-Ok Kim, Young-Jun Ju, Yoon-Chul Kye, Gil-Woo Lee, Sung-Woo Lee, Cheol-Heui Yun, Nunzio Bottini, Kylie Webster, Christopher C. Goodnow, Charles D. Surh, Cecile King, Jonathan Sprent
Published 2016-11-01

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.

by Erkan Kiris, Jonathan E Nuss, Stephanie M Stanford, Laura M Wanner, Lisa Cazares, Michael F Maestre, Hao T Du, Glenn Y Gomba, James C Burnett, Rick Gussio, Nunzio Bottini, Rekha G Panchal, Christopher D Kane, Lino Tessarollo, Sina Bavari
Published 2015-01-01

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

by Cristiano Sacchetti, Yunpeng Bai, Stephanie M. Stanford, Paola Di Benedetto, Paola Cipriani, Eugenio Santelli, Sonsoles Piera-Velazquez, Vladimir Chernitskiy, William B. Kiosses, Arnold Ceponis, Klaus H. Kaestner, Francesco Boin, Sergio A. Jimenez, Roberto Giacomelli, Zhong-Yin Zhang, Nunzio Bottini
Published 2017-10-01