Mutation-Specific Mechanisms of Hyperactivation of Noonan Syndrome SOS Molecules Detected with Single-molecule Imaging in Living Cells

by Yuki Nakamura, Nobuhisa Umeki, Mitsuhiro Abe, Yasushi Sako
Published 2017-10-01

Biphasic spatiotemporal regulation of GRB2 dynamics by p52SHC for transient RAS activation

by Ryo Yoshizawa, Nobuhisa Umeki, Akihiro Yamamoto, Masayuki Murata, Yasushi Sako
Published 2021-02-01

Stretching actin filaments within cells enhances their affinity for the myosin II motor domain.

by Taro Q P Uyeda, Yoshiaki Iwadate, Nobuhisa Umeki, Akira Nagasaki, Shigehiko Yumura
Published 2011-01-01

K336I mutant actin alters the structure of neighbouring protomers in filaments and reduces affinity for actin-binding proteins

by Nobuhisa Umeki, Keitaro Shibata, Taro Q. P. Noguchi, Keiko Hirose, Yasushi Sako, Taro Q. P. Uyeda
Published 2019-03-01