Heterologous expression of Ralp3 in Streptococcus pyogenes M2 and M6 strains affects the virulence characteristics.

by Nikolai Siemens, Bernd Kreikemeyer
Published 2013-01-01

<i>Streptococcus pyogenes</i> (“Group A Streptococcus”), a Highly Adapted Human Pathogen—Potential Implications of Its Virulence Regulation for Epidemiology and Disease Management...

by Nikolai Siemens, Rudolf Lütticken
Published 2021-06-01

The Role of Streptococcal and Staphylococcal Exotoxins and Proteases in Human Necrotizing Soft Tissue Infections

by Patience Shumba, Srikanth Mairpady Shambat, Nikolai Siemens
Published 2019-06-01

Port d’Entrée for Respiratory Infections – Does the Influenza A Virus Pave the Way for Bacteria?

by Nikolai Siemens, Nikolai Siemens, Sonja Oehmcke-Hecht, Thomas C. Mettenleiter, Bernd Kreikemeyer, Peter Valentin-Weigand, Sven Hammerschmidt
Published 2017-12-01

The Role of NLRP3 Inflammasome in Pneumococcal Infections

by Surabhi Surabhi, Fabian Cuypers, Sven Hammerschmidt, Nikolai Siemens
Published 2020-12-01

Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1β Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells

by Surabhi Surabhi, Lana H. Jachmann, Patience Shumba, Gerhard Burchhardt, Sven Hammerschmidt, Nikolai Siemens
Published 2021-08-01

16HBE Cell Lipid Mediator Responses to Mono and Co-Infections with Respiratory Pathogens

by Daniel Schultz, Surabhi Surabhi, Nicolas Stelling, Michael Rothe, KoInfekt Study Group, Karen Methling, Sven Hammerschmidt, Nikolai Siemens, Michael Lalk
Published 2020-03-01

Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse.

by Karthickeyan Chella Krishnan, Santhosh Mukundan, Jeyashree Alagarsamy, Junguk Hur, Suba Nookala, Nikolai Siemens, Mattias Svensson, Ole Hyldegaard, Anna Norrby-Teglund, Malak Kotb
Published 2016-07-01

Modelling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology

by Srikanth Mairpady Shambat, Puran Chen, Anh Thu Nguyen Hoang, Helena Bergsten, Francois Vandenesch, Nikolai Siemens, Gerard Lina, Ian R. Monk, Timothy J. Foster, Gayathri Arakere, Mattias Svensson, Anna Norrby-Teglund
Published 2015-11-01

Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment

by Nikolai Siemens, Sonja Oehmcke-Hecht, Jörn Hoßmann, Sebastian B. Skorka, Roel H.T. Nijhuis, Corinne Ruppen, Steinar Skrede, Manfred Rohde, Daniel Schultz, Michael Lalk, Andreas Itzek, Dietmar H. Pieper, Christiaan J. van den Bout, Eric C.J. Claas, Ed J. Kuijper, Robert Mauritz, Parham Sendi, Herman F. Wunderink, Anna Norrby-Teglund
Published 2019-11-01