Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes

by Nika M. Strokappe, Miriam Hock, Lucy Rutten, Laura E. Mccoy, Jaap W. Back, Christophe Caillat, Matthias Haffke, Robin A. Weiss, Winfried Weissenhorn, Theo Verrips
Published 2019-06-01

A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers

by Lucy Rutten, Yen-Ting Lai, Sven Blokland, Daphne Truan, Ilona J.M. Bisschop, Nika M. Strokappe, Annemart Koornneef, Danielle van Manen, Gwo-Yu Chuang, S. Katie Farney, Hanneke Schuitemaker, Peter D. Kwong, Johannes P.M. Langedijk
Published 2018-04-01

Molecular evolution of broadly neutralizing Llama antibodies to the CD4-binding site of HIV-1.

by Laura E McCoy, Lucy Rutten, Dan Frampton, Ian Anderson, Luke Granger, Rachael Bashford-Rogers, Gillian Dekkers, Nika M Strokappe, Michael S Seaman, Willie Koh, Vanina Grippo, Alexander Kliche, Theo Verrips, Paul Kellam, Ariberto Fassati, Robin A Weiss
Published 2014-12-01

A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition.

by David Lutje Hulsik, Ying-ying Liu, Nika M Strokappe, Simone Battella, Mohamed El Khattabi, Laura E McCoy, Charles Sabin, Andreas Hinz, Miriam Hock, Pauline Macheboeuf, Alexandre M J J Bonvin, Johannes P M Langedijk, David Davis, Anna Forsman Quigley, Marlén M I Aasa-Chapman, Michael S Seaman, Alejandra Ramos, Pascal Poignard, Adrien Favier, Jean-Pierre Simorre, Robin A Weiss, C Theo Verrips, Winfried Weissenhorn, Lucy Rutten
Published 2013-03-01