Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: Predictions for Medical Translation that Survived the “Test of Time”

by Matthias J. Reddehase, Niels A. W. Lemmermann
Published 2018-12-01

Direct Evidence for Viral Antigen Presentation during Latent Cytomegalovirus Infection

by Niels A. W. Lemmermann, Matthias J. Reddehase
Published 2021-06-01

Consequence of Histoincompatibility beyond GvH-Reaction in Cytomegalovirus Disease Associated with Allogeneic Hematopoietic Cell Transplantation: Change of Paradigm

by Matthias J. Reddehase, Rafaela Holtappels, Niels A. W. Lemmermann
Published 2021-08-01

The p36 Isoform of Murine Cytomegalovirus m152 Protein Suffices for Mediating Innate and Adaptive Immune Evasion

by Annette Fink, Angeliqué Renzaho, Matthias J. Reddehase, Niels A. W. Lemmermann
Published 2013-12-01

Localization of Viral Epitope-Specific CD8 T Cells during Cytomegalovirus Latency in the Lungs and Recruitment to Lung Parenchyma by Airway Challenge Infection

by Franziska Blaum, Dominika Lukas, Matthias J. Reddehase, Niels A. W. Lemmermann
Published 2021-09-01

Revisiting CD8 T-cell ‘Memory Inflation’: New Insights with Implications for Cytomegaloviruses as Vaccine Vectors

by Rafaela Holtappels, Kirsten Freitag, Angelique Renzaho, Sara Becker, Niels A.W. Lemmermann, Matthias J. Reddehase
Published 2020-07-01

Cytomegalovirus-Associated Inhibition of Hematopoiesis Is Preventable by Cytoimmunotherapy With Antiviral CD8 T Cells

by Angelique Renzaho, Jürgen Podlech, Birgit Kühnapfel, Franziska Blaum, Matthias J. Reddehase, Niels A. W. Lemmermann
Published 2020-04-01

Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic C...

by Emin Gezinir, Jürgen Podlech, Kerstin M. Gergely, Sara Becker, Matthias J. Reddehase, Niels A. W. Lemmermann
Published 2020-06-01

Noncanonical Expression of a Murine Cytomegalovirus Early Protein CD8 T-Cell Epitope as an Immediate Early Epitope Based on Transcription from an Upstream Gene

by Annette Fink, Julia K. Büttner, Doris Thomas, Rafaela Holtappels, Matthias J. Reddehase, Niels A. W. Lemmermann
Published 2014-02-01

Stochastic Episodes of Latent Cytomegalovirus Transcription Drive CD8 T-Cell “Memory Inflation” and Avoid Immune Evasion

by Marion Griessl, Angelique Renzaho, Kirsten Freitag, Christof K. Seckert, Matthias J. Reddehase, Niels A. W. Lemmermann
Published 2021-04-01

Reverse Genetics Modification of Cytomegalovirus Antigenicity and Immunogenicity by CD8 T-Cell Epitope Deletion and Insertion

by Niels A. W. Lemmermann, Kai A. Kropp, Christof K. Seckert, Natascha K. A. Grzimek, Matthias J. Reddehase
Published 2011-01-01

Insufficient Antigen Presentation Due to Viral Immune Evasion Explains Lethal Cytomegalovirus Organ Disease After Allogeneic Hematopoietic Cell Transplantation

by Rafaela Holtappels, Sina I. Schader, Oliver Oettel, Jürgen Podlech, Christof K. Seckert, Matthias J. Reddehase, Niels A. W. Lemmermann
Published 2020-04-01

Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice.

by Simone Thomas, Sebastian Klobuch, Jürgen Podlech, Bodo Plachter, Petra Hoffmann, Angelique Renzaho, Matthias Theobald, Matthias J Reddehase, Wolfgang Herr, Niels A W Lemmermann
Published 2015-07-01

Therapeutic Vaccination of Hematopoietic Cell Transplantation Recipients Improves Protective CD8 T-Cell Immunotherapy of Cytomegalovirus Infection

by Kerstin M. Gergely, Jürgen Podlech, Sara Becker, Kirsten Freitag, Steffi Krauter, Nicole Büscher, Rafaela Holtappels, Bodo Plachter, Matthias J. Reddehase, Niels A. W. Lemmermann
Published 2021-08-01

Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread.

by Niels A W Lemmermann, Astrid Krmpotic, Jürgen Podlech, Ilija Brizic, Adrian Prager, Heiko Adler, Astrid Karbach, Yiquan Wu, Stipan Jonjic, Matthias J Reddehase, Barbara Adler
Published 2015-02-01

Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells.

by Sebastian Reuter, Niels A W Lemmermann, Joachim Maxeiner, Jürgen Podlech, Hendrik Beckert, Kirsten Freitag, Daniel Teschner, Frederic Ries, Christian Taube, Roland Buhl, Matthias J Reddehase, Rafaela Holtappels
Published 2019-03-01

Mast cells expedite control of pulmonary murine cytomegalovirus infection by enhancing the recruitment of protective CD8 T cells to the lungs.

by Stefan Ebert, Marc Becker, Niels A W Lemmermann, Julia K Büttner, Anastasija Michel, Christian Taube, Jürgen Podlech, Verena Böhm, Kirsten Freitag, Doris Thomas, Rafaela Holtappels, Matthias J Reddehase, Michael Stassen
Published 2014-04-01

The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages.

by Nadine Thiel, Kirsten A Keyser, Niels A W Lemmermann, Jennifer D Oduro, Karen Wagner, Carina Elsner, Anne Halenius, Tihana Lenac Roviš, Melanie M Brinkmann, Stipan Jonjić, Luka Cicin-Sain, Martin Messerle
Published 2016-12-01

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.

by Baca Chan, Vladimir Gonçalves Magalhães, Niels A W Lemmermann, Vanda Juranić Lisnić, Markus Stempel, Kendra A Bussey, Elisa Reimer, Jürgen Podlech, Stefan Lienenklaus, Matthias J Reddehase, Stipan Jonjić, Melanie M Brinkmann
Published 2017-05-01

No Evidence for Classic Thrombotic Microangiopathy in COVID-19

by Tanja Falter, Heidi Rossmann, Philipp Menge, Jan Goetje, Steffen Groenwoldt, Arndt Weinmann, Visvakanth Sivanathan, Andreas Schulz, Niels A. W. Lemmermann, Sven Danckwardt, Karl J. Lackner, Peter R. Galle, Inge Scharrer, Bernhard Lämmle, Martin F. Sprinzl
Published 2021-02-01