Senolytic Targeting of Bcl-2 Anti-Apoptotic Family Increases Cell Death in Irradiated Sarcoma Cells

by Julie Lafontaine, Guillaume B. Cardin, Nicolas Malaquin, Jean-Sébastien Boisvert, Francis Rodier, Philip Wong
Published 2021-01-01

Senescent fibroblasts enhance early skin carcinogenic events via a paracrine MMP-PAR-1 axis.

by Nicolas Malaquin, Chantal Vercamer, Fatima Bouali, Sébastien Martien, Emeric Deruy, Nicolas Wernert, Maggy Chwastyniak, Florence Pinet, Corinne Abbadie, Albin Pourtier
Published 2013-01-01

DNA Damage- But Not Enzalutamide-Induced Senescence in Prostate Cancer Promotes Senolytic Bcl-xL Inhibitor Sensitivity

by Nicolas Malaquin, Arthur Vancayseele, Sophie Gilbert, Laureen Antenor-Habazac, Marc-Alexandre Olivier, Zakia Ait Ali Brahem, Fred Saad, Guila Delouya, Francis Rodier
Published 2020-07-01

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

by Joe Nassour, Sébastien Martien, Nathalie Martin, Emeric Deruy, Elisa Tomellini, Nicolas Malaquin, Fatima Bouali, Laure Sabatier, Nicolas Wernert, Sébastien Pinte, Eric Gilson, Albin Pourtier, Olivier Pluquet, Corinne Abbadie
Published 2016-01-01

Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

by Hubert Fleury, Nicolas Malaquin, Véronique Tu, Sophie Gilbert, Aurélie Martinez, Marc-Alexandre Olivier, Alexandre Sauriol, Laudine Communal, Kim Leclerc-Desaulniers, Euridice Carmona, Diane Provencher, Anne-Marie Mes-Masson, Francis Rodier
Published 2019-06-01

Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia

by Sophia Morel, Pauline Léveillé, Mariia Samoilenko, Anita Franco, Jade England, Nicolas Malaquin, Véronique Tu, Guillaume B. Cardin, Simon Drouin, Francis Rodier, Sarah Lippé, Maja Krajinovic, Caroline Laverdière, Daniel Sinnett, Geneviève Lefebvre, Emile Levy, Valérie Marcil
Published 2020-12-01