The TLR4 D299G and T399I SNPs are constitutively active to up-regulate expression of Trif-dependent genes.

by Georgina L Hold, Susan Berry, Karin A Saunders, Janice Drew, Claus Mayer, Heather Brookes, Nick J Gay, Emad M El-Omar, Clare E Bryant
Published 2014-01-01

Impact of mutations in Toll-like receptor pathway genes on esophageal carcinogenesis.

by Daffolyn Rachael Fels Elliott, Juliane Perner, Xiaodun Li, Martyn F Symmons, Brett Verstak, Matthew Eldridge, Lawrence Bower, Maria O'Donovan, Nick J Gay, OCCAMS Consortium, Rebecca C Fitzgerald
Published 2017-05-01

Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

by Anne Marit de Groot, Kaushik Thanki, Monique Gangloff, Emily Falkenberg, Xianghui Zeng, Djai C.J. van Bijnen, Willem van Eden, Henrik Franzyk, Hanne M. Nielsen, Femke Broere, Nick J. Gay, Camilla Foged, Alice J.A.M. Sijts
Published 2018-06-01