An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite tre...

by Stuart Ainsworth, Stefanie K Menzies, Nicholas R Casewell, Robert A Harrison
Published 2020-08-01

Immunological Cross-Reactivity and Neutralisation of European Viper Venoms with the Monospecific Vipera berus Antivenom ViperaTAb

by Nicholas R. Casewell, Ibrahim Al-Abdulla, David Smith, Ruth Coxon, John Landon
Published 2014-08-01

Clinical outcomes and outcome measurement tools reported in randomised controlled trials of treatment for snakebite envenoming: A systematic review.

by Michael Abouyannis, Dinesh Aggarwal, David G Lalloo, Nicholas R Casewell, Mainga Hamaluba, Hanif Esmail
Published 2021-08-01

Novel Snakebite Therapeutics Must Be Tested in Appropriate Rescue Models to Robustly Assess Their Preclinical Efficacy

by Cecilie Knudsen, Nicholas R. Casewell, Bruno Lomonte, José María Gutiérrez, Sakthivel Vaiyapuri, Andreas H. Laustsen
Published 2020-08-01

A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite

by Laura-Oana Albulescu, Taline Kazandjian, Julien Slagboom, Ben Bruyneel, Stuart Ainsworth, Jaffer Alsolaiss, Simon C. Wagstaff, Gareth Whiteley, Robert A. Harrison, Robert A. Harrison, Chris Ulens, Jeroen Kool, Nicholas R. Casewell, Nicholas R. Casewell
Published 2019-07-01

Multipurpose HTS Coagulation Analysis: Assay Development and Assessment of Coagulopathic Snake Venoms

by Kristina B. M. Still, Randjana S. S. Nandlal, Julien Slagboom, Govert W. Somsen, Nicholas R. Casewell, Jeroen Kool
Published 2017-11-01

Isolation and characterization of cytotoxic and insulin-releasing components from the venom of the black-necked spitting cobra Naja nigricollis (Elapidae)

by J.M. Conlon, Samir Attoub, Vishal Musale, Jérôme Leprince, Nicholas R. Casewell, Libia Sanz, Juan J. Calvete
Published 2020-06-01

Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms

by Chunfang Xie, Julien Slagboom, Laura-Oana Albulescu, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool
Published 2020-10-01

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches.

by Julien Slagboom, Marija Mladić, Chunfang Xie, Taline D Kazandjian, Freek Vonk, Govert W Somsen, Nicholas R Casewell, Jeroen Kool
Published 2020-04-01

Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic <i>Viperinae</i> Snake Venom Toxins

by Chunfang Xie, Laura-Oana Albulescu, Mátyás A. Bittenbinder, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool
Published 2020-08-01

In Vitro Immunological Cross-Reactivity of Thai Polyvalent and Monovalent Antivenoms with Asian Viper Venoms

by Janeyuth Chaisakul, Muhamad Rusdi Ahmad Rusmili, Jaffer Alsolaiss, Laura-Oana Albulescu, Robert A. Harrison, Iekhsan Othman, Nicholas R. Casewell
Published 2020-12-01

Pre-clinical assays predict pan-African Echis viper efficacy for a species-specific antivenom.

by Nicholas R Casewell, Darren A N Cook, Simon C Wagstaff, Abdulsalami Nasidi, Nandul Durfa, Wolfgang Wüster, Robert A Harrison
Published 2010-10-01

Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy.

by R R Senji Laxme, Saurabh Attarde, Suyog Khochare, Vivek Suranse, Gerard Martin, Nicholas R Casewell, Romulus Whitaker, Kartik Sunagar
Published 2021-02-01

Multifunctional Toxins in Snake Venoms and Therapeutic Implications: From Pain to Hemorrhage and Necrosis

by Camila R. Ferraz, Camila R. Ferraz, Arif Arrahman, Chunfang Xie, Nicholas R. Casewell, Richard J. Lewis, Jeroen Kool, Fernanda C. Cardoso
Published 2019-06-01

Genome-wide data implicate terminal fusion automixis in king cobra facultative parthenogenesis

by Daren C. Card, Freek J. Vonk, Sterrin Smalbrugge, Nicholas R. Casewell, Wolfgang Wüster, Todd A. Castoe, Gordon W. Schuett, Warren Booth
Published 2021-03-01

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

by José María Gutiérrez, Laura-Oana Albulescu, Rachel H. Clare, Nicholas R. Casewell, Tarek Mohamed Abd El-Aziz, Teresa Escalante, Alexandra Rucavado
Published 2021-06-01

Biogeographic venom variation in Russell's viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots.

by R R Senji Laxme, Suyog Khochare, Saurabh Attarde, Vivek Suranse, Ashwin Iyer, Nicholas R Casewell, Romulus Whitaker, Gerard Martin, Kartik Sunagar
Published 2021-03-01

Evaluation of the geographical utility of Eastern Russell's viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephr...

by Janeyuth Chaisakul, Jaffer Alsolaiss, Mongkon Charoenpitakchai, Kulachet Wiwatwarayos, Nattapon Sookprasert, Robert A Harrison, Narongsak Chaiyabutr, Lawan Chanhome, Choo Hock Tan, Nicholas R Casewell
Published 2019-10-01

Anticoagulant Activity of <i>Naja nigricollis</i> Venom is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib

by Taline D. Kazandjian, Arif Arrahman, Kristina B.M. Still, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Mark C. Wilkinson, Jeroen Kool
Published 2021-04-01

Pharmacological Characterisation of <i>Pseudocerastes</i> and <i>Eristicophis</i> Viper Venoms Reveal Anticancer (Melanoma) Properties and a Potentially Novel Mode of Fibrinogenoly...

by Bianca op den Brouw, Parviz Ghezellou, Nicholas R. Casewell, Syed Abid Ali, Behzad Fathinia, Bryan G. Fry, Mettine H.A. Bos, Maria P. Ikonomopoulou
Published 2021-06-01