Metabolic erosion primarily through mutation accumulation, and not tradeoffs, drives limited evolution of substrate specificity in Escherichia coli.

by Nicholas Leiby, Christopher J Marx
Published 2014-02-01

The ability of flux balance analysis to predict evolution of central metabolism scales with the initial distance to the optimum.

by William R Harcombe, Nigel F Delaney, Nicholas Leiby, Niels Klitgord, Christopher J Marx
Published 2013-01-01

Metabolic Resource Allocation in Individual Microbes Determines Ecosystem Interactions and Spatial Dynamics

by William R. Harcombe, William J. Riehl, Ilija Dukovski, Brian R. Granger, Alex Betts, Alex H. Lang, Gracia Bonilla, Amrita Kar, Nicholas Leiby, Pankaj Mehta, Christopher J. Marx, Daniel Segrè
Published 2014-05-01