Advances in Precision Medicine: Tailoring Individualized Therapies

by Kyle B. Matchett, Niamh Lynam-Lennon, R. William Watson, James A. L. Brown
Published 2017-10-01

Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers

by Abdullah Alhusaini, Aoife Cannon, Stephen G. Maher, John V. Reynolds, Niamh Lynam-Lennon
Published 2021-08-01

Complement in Tumourigenesis and the Response to Cancer Therapy

by Rebecca M. O’Brien, Aoife Cannon, John V. Reynolds, Joanne Lysaght, Niamh Lynam-Lennon
Published 2021-03-01

Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma.

by Niamh Lynam-Lennon, Stephen G Maher, Aoife Maguire, James Phelan, Cian Muldoon, John V Reynolds, Jacintha O'Sullivan
Published 2014-01-01

Low MiR-187 Expression Promotes Resistance to Chemoradiation Therapy In Vitro and Correlates with Treatment Failure in Patients with Esophageal Adenocarcinoma

by Niamh Lynam-Lennon, Becky A S Bibby, Ann Marie Mongan, Laure Marignol, Christian N Paxton, Katherine Geiersbach, Mary P Bronner, Jacintha O’Sullivan, John V Reynolds, Stephen G Maher
Published 2016-05-01

Chemotherapy regimens induce inhibitory immune checkpoint protein expression on stem-like and senescent-like oesophageal adenocarcinoma cells

by Maria Davern, Noel E. Donlon, Andrew Sheppard, Fiona O’ Connell, Conall Hayes, Anshul Bhardwaj, Emma Foley, Dermot O’ Toole, Niamh Lynam-Lennon, Narayanasamy Ravi, John V. Reynolds, Stephen G. Maher, Joanne Lysaght
Published 2021-06-01

Prediction of pathological response to neo‐adjuvant chemoradiotherapy for oesophageal cancer using vibrational spectroscopy

by Thi N. Q. Nguyen, Adrian Maguire, Catherine Mooney, Naomi Jackson, Niamh Lynam‐Lennon, Vicki Weldon, Cian Muldoon, Aoife A. Maguire, D. O'Toole, Narayanasamy Ravi, John V. Reynolds, Jacintha O'Sullivan, Aidan D. Meade
Published 2021-03-01

The Protein Secretome Is Altered in Rectal Cancer Tissue Compared to Normal Rectal Tissue, and Alterations in the Secretome Induce Enhanced Innate Immune Responses

by Aisling B. Heeran, Margaret R. Dunne, Maria E. Morrissey, Croí E. Buckley, Niamh Clarke, Aoife Cannon, Noel E. Donlon, Timothy S. Nugent, Michael Durand, Cara Dunne, John O. Larkin, Brian Mehigan, Paul McCormick, Niamh Lynam-Lennon, Jacintha O’Sullivan
Published 2021-02-01

Radiation-induced Bystander Effect (RIBE) alters mitochondrial metabolism using a human rectal cancer ex vivo explant model

by Aisling B. Heeran, Helen P. Berrigan, Croí E. Buckley, Heleena Moni Bottu, Orla Prendiville, Amy M. Buckley, Niamh Clarke, Noel E. Donlon, Timothy S. Nugent, Michael Durand, Cara Dunne, John O. Larkin, Brian Mehigan, Paul McCormick, Lorraine Brennan, Niamh Lynam-Lennon, Jacintha O'Sullivan
Published 2021-01-01

The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation

by Maria E. Morrissey, Róisín Byrne, Celina Nulty, Niamh H. McCabe, Niamh Lynam-Lennon, Clare T. Butler, Susan Kennedy, Dermot O’Toole, John Larkin, Paul McCormick, Brian Mehigan, Mary-Clare Cathcart, Joanne Lysaght, John V. Reynolds, Elizabeth J. Ryan, Margaret R. Dunne, Jacintha O’Sullivan
Published 2020-06-01