Evolutionary signatures amongst disease genes permit novel methods for gene prioritization and construction of informative gene-based networks.

by Nolan Priedigkeit, Nicholas Wolfe, Nathan L Clark
Published 2015-02-01

Pan-mammalian analysis of molecular constraints underlying extended lifespan

by Amanda Kowalczyk, Raghavendran Partha, Nathan L Clark, Maria Chikina
Published 2020-02-01

Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape.

by Dustin C Hancks, Melissa K Hartley, Celia Hagan, Nathan L Clark, Nels C Elde
Published 2015-05-01

Evolutionary rate covariation identifies new members of a protein network required for Drosophila melanogaster female post-mating responses.

by Geoffrey D Findlay, Jessica L Sitnik, Wenke Wang, Charles F Aquadro, Nathan L Clark, Mariana F Wolfner
Published 2014-01-01

Subterranean mammals show convergent regression in ocular genes and enhancers, along with adaptation to tunneling

by Raghavendran Partha, Bharesh K Chauhan, Zelia Ferreira, Joseph D Robinson, Kira Lathrop, Ken K Nischal, Maria Chikina, Nathan L Clark
Published 2017-10-01

Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila.

by Qanber Raza, Jae Young Choi, Yang Li, Roisin M O'Dowd, Simon C Watkins, Maria Chikina, Yang Hong, Nathan L Clark, Adam V Kwiatkowski
Published 2019-02-01

A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency

by Dana M Talsness, Katie G Owings, Emily Coelho, Gaelle Mercenne, John M Pleinis, Raghavendran Partha, Kevin A Hope, Aamir R Zuberi, Nathan L Clark, Cathleen M Lutz, Aylin R Rodan, Clement Y Chow
Published 2020-12-01

MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage

by Jen-Wei Huang, Ananya Acharya, Angelo Taglialatela, Tarun S. Nambiar, Raquel Cuella-Martin, Giuseppe Leuzzi, Samuel B. Hayward, Sarah A. Joseph, Gregory J. Brunette, Roopesh Anand, Rajesh K. Soni, Nathan L. Clark, Kara A. Bernstein, Petr Cejka, Alberto Ciccia
Published 2020-06-01