Reproducible preclinical research-Is embracing variability the answer?

by Natasha A Karp
Published 2018-03-01

What is the optimum design for my animal experiment?

by Natasha A Karp, Derek Fry
Published 2021-07-01

A common control group - optimising the experiment design to maximise sensitivity.

by Simon Bate, Natasha A Karp
Published 2014-01-01

Robust and sensitive analysis of mouse knockout phenotypes.

by Natasha A Karp, David Melvin, Sanger Mouse Genetics Project, Richard F Mott
Published 2012-01-01

PhenStat: A Tool Kit for Standardized Analysis of High Throughput Phenotypic Data.

by Natalja Kurbatova, Jeremy C Mason, Hugh Morgan, Terrence F Meehan, Natasha A Karp
Published 2015-01-01

Optimizing the design of population-based patient-derived tumor xenograft studies to better predict clinical response

by Nicolas Floc'h, Maria Luisa Guerriero, Antonio Ramos-Montoya, Barry R. Davies, Jonathan Cairns, Natasha A. Karp
Published 2018-11-01

Impact of temporal variation on design and analysis of mouse knockout phenotyping studies.

by Natasha A Karp, Anneliese O Speak, Jacqueline K White, David J Adams, Martin Hrabé de Angelis, Yann Hérault, Richard F Mott
Published 2014-01-01

The Experimental Design Assistant.

by Nathalie Percie du Sert, Ian Bamsey, Simon T Bate, Manuel Berdoy, Robin A Clark, Innes Cuthill, Derek Fry, Natasha A Karp, Malcolm Macleod, Lawrence Moon, S Clare Stanford, Brian Lings
Published 2017-09-01

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen

by Hibret A. Adissu, Jeanne Estabel, David Sunter, Elizabeth Tuck, Yvette Hooks, Damian M. Carragher, Kay Clarke, Natasha A. Karp, Sanger Mouse Genetics Project, Susan Newbigging, Nora Jones, Lily Morikawa, Jacqueline K. White, Colin McKerlie
Published 2014-05-01

Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project.

by William S Redfern, Karen Tse, Claire Grant, Amy Keerie, David J Simpson, John C Pedersen, Victoria Rimmer, Lauren Leslie, Stephanie K Klein, Natasha A Karp, Rowland Sillito, Agis Chartsias, Tim Lukins, James Heward, Catherine Vickers, Kathryn Chapman, J Douglas Armstrong
Published 2017-01-01

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

by Gabriel Balmus, Delphine Larrieu, Ana C. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J. Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A. Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J. Adams, Stephen P. Jackson
Published 2018-04-01

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection.

by María A Duque-Correa, Natasha A Karp, Catherine McCarthy, Simon Forman, David Goulding, Geetha Sankaranarayanan, Timothy P Jenkins, Adam J Reid, Emma L Cambridge, Carmen Ballesteros Reviriego, Sanger Mouse Genetics Project, 3i consortium, Werner Müller, Cinzia Cantacessi, Gordon Dougan, Richard K Grencis, Matthew Berriman
Published 2019-01-01

Revision of the ARRIVE guidelines: rationale and scope

by Nathalie Percie du Sert, Viki Hurst, Marc T Avey, Monya Baker, William Browne, Alejandra Clark, Innes C Cuthill, Michael Emerson, David W Howells, Natasha A Karp, Catriona J MacCallum, Ole Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S Sena, Shai D Silberberg, Thomas Steckler, Hanno Würbel
Published 2018-10-01

Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.

by Simon Maguire, Jeanne Estabel, Neil Ingham, Selina Pearson, Edward Ryder, Damian M Carragher, Nicolas Walker, Sanger MGP Slc25a21 Project Team, James Bussell, Wai-In Chan, Thomas M Keane, David J Adams, Cheryl L Scudamore, Christopher J Lelliott, Ramiro Ramírez-Solis, Natasha A Karp, Karen P Steel, Jacqueline K White, Anna-Karin Gerdin
Published 2014-01-01

A gene expression resource generated by genome-wide lacZ profiling in the mouse

by Elizabeth Tuck, Jeanne Estabel, Anika Oellrich, Anna Karin Maguire, Hibret A. Adissu, Luke Souter, Emma Siragher, Charlotte Lillistone, Angela L. Green, Hannah Wardle-Jones, Damian M. Carragher, Natasha A. Karp, Damian Smedley, Niels C. Adams, Sanger Institute Mouse Genetics Project, James N. Bussell, David J. Adams, Ramiro Ramírez-Solis, Karen P. Steel, Antonella Galli, Jacqueline K. White
Published 2015-11-01

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.

by Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T Avey, Monya Baker, William J Browne, Alejandra Clark, Innes C Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T Holgate, David W Howells, Natasha A Karp, Stanley E Lazic, Katie Lidster, Catriona J MacCallum, Malcolm Macleod, Esther J Pearl, Ole H Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S Sena, Shai D Silberberg, Thomas Steckler, Hanno Würbel
Published 2020-07-01

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.

by Nathalie Percie du Sert, Amrita Ahluwalia, Sabina Alam, Marc T Avey, Monya Baker, William J Browne, Alejandra Clark, Innes C Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T Holgate, David W Howells, Viki Hurst, Natasha A Karp, Stanley E Lazic, Katie Lidster, Catriona J MacCallum, Malcolm Macleod, Esther J Pearl, Ole H Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S Sena, Shai D Silberberg, Thomas Steckler, Hanno Würbel
Published 2020-07-01

The ARRIVE guidelines 2.0: updated guidelines for reporting animal research

by Paul Garner, Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T Avey, Monya Baker, Alejandra Clark, Innes C Cuthill, Ulrich Dirnagl, Michael Emerson, David W Howells, Natasha A Karp, Catriona J MacCallum, Malcolm Macleod, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S Sena, Shai D Silberberg, Thomas Steckler, Stephen T Holgate, Hanno Wuerbel, Ole H Petersen, William J Browne, Stanley E Lazic, Katie Lidster, Esther J Pearl
Published 2020-11-01

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

by Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T. Avey, Monya Baker, William J. Browne, Alejandra Clark, Innes C. Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T. Holgate, David W. Howells, Natasha A. Karp, Stanley E. Lazic, Katie Lidster, Catriona J. MacCallum, Malcolm Macleod, Esther J. Pearl, Ole H. Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S. Sena, Shai D. Silberberg, Thomas Steckler, Hanno Würbel
Published 2020-07-01

Applying the ARRIVE Guidelines to an In Vivo Database.

by Natasha A Karp, Terry F Meehan, Hugh Morgan, Jeremy C Mason, Jeremy C Mason, Andrew Blake, Natalja Kurbatova, Damian Smedley, Julius Jacobsen, Richard F Mott, Vivek Iyer, Peter Matthews, David G Melvin, Sara Wells, Ann M Flenniken, Hiroshi Masuya, Shigeharu Wakana, Jacqueline K White, K C Kent Lloyd, Corey L Reynolds, Richard Paylor, David B West, Karen L Svenson, Elissa J Chesler, Martin Hrabě de Angelis, Glauco P Tocchini-Valentini, Tania Sorg, Yann Herault, Helen Parkinson, Ann-Marie Mallon, Steve D M Brown
Published 2015-05-01