Sirolimus Pharmacokinetics Variability Points to the Relevance of Therapeutic Drug Monitoring in Pediatric Oncology

by Amelia-Naomi Sabo, Sarah Jannier, Guillaume Becker, Jean-Marc Lessinger, Natacha Entz-Werlé, Véronique Kemmel
Published 2021-03-01

Role of Topoisomerases in Pediatric High Grade Osteosarcomas: TOP2A Gene Is One of the Unique Molecular Biomarkers of Chemoresponse

by Natacha Entz-Werle, Dominique Guenot, Marie-Pierre Gaub, Erwan Pencreach, Luc Marcellin, Eric Guerin, Christelle Lasthaus, Aurelia Nguyen
Published 2013-06-01

Hypoxia Inducible Factors’ Signaling in Pediatric High-Grade Gliomas: Role, Modelization and Innovative Targeted Approaches

by Quentin Fuchs, Marina Pierrevelcin, Melissa Messe, Benoit Lhermitte, Anne-Florence Blandin, Christophe Papin, Andres Coca, Monique Dontenwill, Natacha Entz-Werlé
Published 2020-04-01

Focus on Hypoxia-Related Pathways in Pediatric Osteosarcomas and Their Druggability

by Marina Pierrevelcin, Quentin Fuchs, Benoit Lhermitte, Melissa Messé, Eric Guérin, Noelle Weingertner, Sophie Martin, Isabelle Lelong-Rebel, Charlotte Nazon, Monique Dontenwill, Natacha Entz-Werlé
Published 2020-08-01

A DNA Repair and Cell Cycle Gene Expression Signature in Pediatric High-Grade Gliomas: Prognostic and Therapeutic Value

by Natacha Entz-Werlé, Laetitia Poidevin, Petr V. Nazarov, Olivier Poch, Benoit Lhermitte, Marie Pierre Chenard, Hélène Burckel, Eric Guérin, Quentin Fuchs, David Castel, Georges Noel, Laurence Choulier, Monique Dontenwill, Eric Van Dyck
Published 2021-05-01

Involvement of MET/TWIST/APC Combination or the Potential Role of Ossification Factors in Pediatric High-Grade Osteosarcoma Oncogenesis

by Natacha Entz-Werle, Thomas Lavaux, Nadia Metzger, Corinne Stoetzel, Christelle Lasthaus, Perrine Marec, Chantal Kalita, Laurence Brugieres, Helene Pacquement, Claudine Schmitt, Marie-Dominique Tabone, Jean-Claude Gentet, Patrick Lutz, Annie Babin, Pierre Oudet, Marie Pierre Gaub, Fabienne Perrin-Schmitt
Published 2007-08-01

Prognostic impact of blood and urinary angiogenic factor levels at diagnosis and during treatment in patients with osteosarcoma: a prospective study

by Marie-Dominique Tabone, Laurence Brugières, Sophie Piperno-Neumann, Marie-Ange Selva, Perrine Marec-Bérard, Hélène Pacquement, Cyril Lervat, Nadège Corradini, Jean-Claude Gentet, Rémy Couderc, Aurélie Chevance, Céline Mahier-Ait Oukhatar, Natacha Entz-Werle, Jean-Yves Blay, Marie-Cecile Le Deley
Published 2017-06-01

SFCE-RAPIRI Phase I Study of Rapamycin Plus Irinotecan: A New Way to Target Intra-Tumor Hypoxia in Pediatric Refractory Cancers

by Sarah Jannier, Véronique Kemmel, Consuelo Sebastia Sancho, Agathe Chammas, Amelia-Naomie Sabo, Erwan Pencreach, Françoise Farace, Marie Pierre Chenard, Benoit Lhermitte, Birgit Geoerger, Isabelle Aerts, Didier Frappaz, Pierre Leblond, Nicolas André, Stephane Ducassou, Nadège Corradini, Anne Isabelle Bertozzi, Eric Guérin, Florence Vincent, Michel Velten, Natacha Entz-Werle
Published 2020-10-01

CD163-positive tumor-associated macrophages and CD8-positive cytotoxic lymphocytes are powerful diagnostic markers for the therapeutic stratification of osteosarcoma patients: An i...

by Anne Gomez-Brouchet, Claire Illac, Julia Gilhodes, Corinne Bouvier, Sébastien Aubert, Jean-Marc Guinebretiere, Béatrice Marie, Frédérique Larousserie, Natacha Entz-Werlé, Gonzague de Pinieux, Thomas Filleron, Véronique Minard, Vincent Minville, Eric Mascard, François Gouin, Marta Jimenez, Marie-Cécile Ledeley, Sophie Piperno-Neumann, Laurence Brugieres, Françoise Rédini
Published 2017-09-01

Characterization of Macrophages and Osteoclasts in the Osteosarcoma Tumor Microenvironment at Diagnosis: New Perspective for Osteosarcoma Treatment?

by Anne Gomez-Brouchet, Julia Gilhodes, Nathalie Van Acker, Regis Brion, Corinne Bouvier, Pauline Assemat, Nathalie Gaspar, Sebastien Aubert, Jean-Marc Guinebretiere, Beatrice Marie, Frederique Larousserie, Natacha Entz-Werlé, Gonzague de Pinieux, Eric Mascard, Francois Gouin, Pierre Brousset, Marie-Dominique Tabone, Marta Jimenez, Marie-Cecile Le Deley, Jean-Yves Blay, Laurence Brugieres, Sophie Piperno-Neumann, Francoise Rédini
Published 2021-01-01