Genome-scale integration of transcriptome and metabolome unveils squalene synthase and dihydrofolate reductase as targets against AML cells resistant to chemotherapy

by Effrosyni Karakitsou, Carles Foguet, Miriam G. Contreras Mostazo, Nina Kurrle, Frank Schnütgen, Martin Michaelis, Jindrich Cinatl, Silvia Marin, Marta Cascante
Published 2021-01-01

Metabolic Plasticity Is an Essential Requirement of Acquired Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia

by Miriam G. Contreras Mostazo, Nina Kurrle, Marta Casado, Dominik Fuhrmann, Islam Alshamleh, Björn Häupl, Paloma Martín-Sanz, Bernhard Brüne, Hubert Serve, Harald Schwalbe, Frank Schnütgen, Silvia Marin, Marta Cascante
Published 2020-11-01