MLH1 region polymorphisms show a significant association with CpG island shore methylation in a large cohort of healthy individuals.

by Andrea J Savio, Mathieu Lemire, Miralem Mrkonjic, Steven Gallinger, Brent W Zanke, Thomas J Hudson, Bharati Bapat
Published 2012-01-01

Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.

by Miralem Mrkonjic, Nicole M Roslin, Celia M Greenwood, Stavroula Raptis, Aaron Pollett, Peter W Laird, Vaijayanti V Pethe, Theodore Chiang, Darshana Daftary, Elizabeth Dicks, Stephen N Thibodeau, Steven Gallinger, Patrick S Parfrey, H Banfield Younghusband, John D Potter, Thomas J Hudson, John R McLaughlin, Roger C Green, Brent W Zanke, Polly A Newcomb, Andrew D Paterson, Bharati Bapat
Published 2010-10-01