The Role of TL1A and DR3 in Autoimmune and Inflammatory Diseases

by Yoshihiro Aiba, Minoru Nakamura
Published 2013-01-01

T‐495, a novel low cooperative M1 receptor positive allosteric modulator, improves memory deficits associated with cholinergic dysfunction and is characterized by low gastrointesti...

by Takao Mandai, Yuu Sako, Emi Kurimoto, Yuji Shimizu, Minoru Nakamura, Makoto Fushimi, Ryouta Maeda, Maki Miyamoto, Haruhide Kimura
Published 2020-02-01

Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis

by Yuki Hitomi, Kaname Kojima, Minae Kawashima, Yosuke Kawai, Nao Nishida, Yoshihiro Aiba, Michio Yasunami, Masao Nagasaki, Minoru Nakamura, Katsushi Tokunaga
Published 2017-06-01

NFKB1 and MANBA Confer Disease Susceptibility to Primary Biliary Cholangitis via Independent Putative Primary Functional VariantsSummary

by Yuki Hitomi, Ken Nakatani, Kaname Kojima, Nao Nishida, Yosuke Kawai, Minae Kawashima, Yoshihiro Aiba, Masao Nagasaki, Minoru Nakamura, Katsushi Tokunaga
Published 2019-01-01

Serum amyloid A induces NLRP-3-mediated IL-1β secretion in neutrophils.

by Kiyoshi Migita, Yasumori Izumi, Yuka Jiuchi, Hideko Kozuru, Chieko Kawahara, Minoru Nakamura, Tadashi Nakamura, Kazunaga Agematsu, Junya Masumoto, Michio Yasunami, Atsushi Kawakami, Katsumi Eguchi
Published 2014-01-01

STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis

by Satoru Joshita, Takeji Umemura, Minoru Nakamura, Yoshihiko Katsuyama, Soichiro Shibata, Takefumi Kimura, Susumu Morita, Michiharu Komatsu, Akihiro Matsumoto, Kaname Yoshizawa, Hiromi Ishibashi, Eiji Tanaka, Masao Ota
Published 2014-01-01

rs1944919 on chromosome 11q23.1 and its effector genes COLCA1/COLCA2 confer susceptibility to primary biliary cholangitis

by Yuki Hitomi, Yoshihiro Aiba, Yosuke Kawai, Kaname Kojima, Kazuko Ueno, Nao Nishida, Minae Kawashima, Olivier Gervais, Seik-Soon Khor, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura, Makoto Tsuiji
Published 2021-02-01

Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma.

by Shigemune Bekki, Satoru Hashimoto, Kazumi Yamasaki, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Akira Saeki, Tomoyuki Suehiro, Yuki Kugiyama, Asami Beppu, Tamotsu Kuroki, Minoru Nakamura, Masahiro Ito, Hiroshi Yatsuhashi
Published 2020-01-01

Rapid Increase in Serum Low-Density Lipoprotein Cholesterol Concentration during Hepatitis C Interferon-Free Treatment.

by Satoru Hashimoto, Hiroshi Yatsuhashi, Seigo Abiru, Kazumi Yamasaki, Atsumasa Komori, Shinya Nagaoka, Akira Saeki, Shinjiro Uchida, Shigemune Bekki, Yuki Kugiyama, Kazuyoshi Nagata, Minoru Nakamura, Kiyoshi Migita, Kazuhiko Nakao
Published 2016-01-01

Association between Anti-Ganglionic Nicotinic Acetylcholine Receptor (gAChR) Antibodies and HLA-DRB1 Alleles in the Japanese Population.

by Yasuhiro Maeda, Kiyoshi Migita, Osamu Higuchi, Akihiro Mukaino, Hiroshi Furukawa, Atsumasa Komori, Minoru Nakamura, Satoru Hashimoto, Shinya Nagaoka, Seigo Abiru, Hiroshi Yatsuhashi, Hidenori Matsuo, Atsushi Kawakami, Michio Yasunami, Shunya Nakane
Published 2016-01-01

Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever.

by Michio Yasunami, Hitomi Nakamura, Kazunaga Agematsu, Akinori Nakamura, Masahide Yazaki, Dai Kishida, Akihiro Yachie, Tomoko Toma, Junya Masumoto, Hiroaki Ida, Tomohiro Koga, Atsushi Kawakami, Katsumi Eguchi, Hiroshi Furukawa, Tadashi Nakamura, Minoru Nakamura, Kiyoshi Migita
Published 2015-01-01

The contribution of SAA1 polymorphisms to Familial Mediterranean fever susceptibility in the Japanese population.

by Kiyoshi Migita, Kazunaga Agematsu, Junya Masumoto, Hiroaki Ida, Seiyo Honda, Yuka Jiuchi, Yasumori Izumi, Yumi Maeda, Ritei Uehara, Yoshikazu Nakamura, Tomohiro Koga, Atsushi Kawakami, Munetoshi Nakashima, Yuichiro Fujieda, Fumiaki Nonaka, Katsumi Eguchi, Hiroshi Furukawa, Tadashi Nakamura, Minoru Nakamura, Michio Yasunami
Published 2013-01-01

Association of soluble T cell immunoglobulin domain and mucin-3 (sTIM-3) and mac-2 binding protein glycosylation isomer (M2BPGi) in patients with autoimmune hepatitis.

by Kiyoshi Migita, Minoru Nakamura, Yoshihiro Aiba, Hideko Kozuru, Seigo Abiru, Atsumasa Komori, Yuya Fujita, Junpei Temmoku, Tomoyuki Asano, Shuzo Sato, Makiko Furuya, Atsushi Naganuma, Kaname Yoshizawa, Masaaki Shimada, Keisuke Ario, Tomohiko Mannami, Hiroshi Kohno, Toshihiko Kaneyoshi, Takuya Komura, Hiromasa Ohira, Hiroshi Yatsuhashi
Published 2020-01-01

HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: The predisposing role of the DR4/DR8 heterozygous genotype.

by Shomi Oka, Hiroshi Furukawa, Michio Yasunami, Aya Kawasaki, Hitomi Nakamura, Minoru Nakamura, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Satoru Hashimoto, Atsushi Naganuma, Noriaki Naeshiro, Kaname Yoshizawa, Haruhiro Yamashita, Keisuke Ario, Hajime Ohta, Hironori Sakai, Iwao Yabuuchi, Atsushi Takahashi, Kazumichi Abe, Hiroshi Yatsuhashi, Shigeto Tohma, Hiromasa Ohira, Naoyuki Tsuchiya, Kiyoshi Migita
Published 2017-01-01

Association of STAT4 polymorphisms with susceptibility to type-1 autoimmune hepatitis in the Japanese population.

by Kiyoshi Migita, Minoru Nakamura, Seigo Abiru, Yuka Jiuchi, Shinya Nagaoka, Atsumasa Komori, Satoru Hashimoto, Shigemune Bekki, Kazumi Yamasaki, Tatsuji Komatsu, Masaaki Shimada, Hiroshi Kouno, Taizo Hijioka, Motoyuki Kohjima, Makoto Nakamuta, Michio Kato, Kaname Yoshizawa, Hajime Ohta, Yoko Nakamura, Eiichi Takezaki, Hideo Nishimura, Takeaki Sato, Keisuke Ario, Noboru Hirashima, Yukio Oohara, Atsushi Naganuma, Toyokichi Muro, Hironori Sakai, Eiji Mita, Kazuhiro Sugi, Haruhiro Yamashita, Fujio Makita, Hiroshi Yatsuhashi, Hiromi Ishibashi, Michio Yasunami
Published 2013-01-01

Circulating microRNA Profiles in Patients with Type-1 Autoimmune Hepatitis.

by Kiyoshi Migita, Atsumasa Komori, Hideko Kozuru, Yuka Jiuchi, Minoru Nakamura, Michio Yasunami, Hiroshi Furukawa, Seigo Abiru, Kazumi Yamasaki, Shinya Nagaoka, Satoru Hashimoto, Shigemune Bekki, Hiroshi Kamitsukasa, Yoko Nakamura, Hajime Ohta, Masaaki Shimada, Hironao Takahashi, Eiji Mita, Taizo Hijioka, Haruhiro Yamashita, Hiroshi Kouno, Makoto Nakamuta, Keisuke Ario, Toyokichi Muro, Hironori Sakai, Kazuhiro Sugi, Hideo Nishimura, Kaname Yoshizawa, Takeaki Sato, Atsushi Naganuma, Tatsuji Komatsu, Yukio Oohara, Fujio Makita, Minoru Tomizawa, Hiroshi Yatsuhashi
Published 2015-01-01

Integrated GWAS and mRNA Microarray Analysis Identified IFNG and CD40L as the Central Upstream Regulators in Primary Biliary Cholangitis

by Kazuko Ueno, Yoshihiro Aiba, Yuki Hitomi, Shinji Shimoda, Hitomi Nakamura, Olivier Gervais, Yosuke Kawai, Minae Kawashima, Nao Nishida, Seik‐Soon Kohn, Kaname Kojima, Shinji Katsushima, Atsushi Naganuma, Kazuhiro Sugi, Tatsuji Komatsu, Tomohiko Mannami, Kouki Matsushita, Kaname Yoshizawa, Fujio Makita, Toshiki Nikami, Hideo Nishimura, Hiroshi Kouno, Hirotaka Kouno, Hajime Ohta, Takuya Komura, Satoru Tsuruta, Kazuhiko Yamauchi, Tatsuro Kobata, Amane Kitasato, Tamotsu Kuroki, Seigo Abiru, Shinya Nagaoka, Atsumasa Komori, Hiroshi Yatsuhashi, Kiyoshi Migita, Hiromasa Ohira, Atsushi Tanaka, Hajime Takikawa, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura, PBC‐GWAS Consortium in Japan
Published 2020-05-01