Killing Me Softly—Future Challenges in Apoptosis Research

by Mike-Andrew Westhoff, Oliver Brühl, Lisa Nonnenmacher, Georg Karpel-Massler, Klaus-Michael Debatin
Published 2014-03-01

Critical View of Novel Treatment Strategies for Glioblastoma: Failure and Success of Resistance Mechanisms by Glioblastoma Cells

by Timo Burster, Rebecca Traut, Zhanerke Yermekkyzy, Katja Mayer, Mike-Andrew Westhoff, Joachim Bischof, Uwe Knippschild
Published 2021-08-01

Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma

by Enyuan Shang, Trang T. T. Nguyen, Chang Shu, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Published 2020-08-01

Cerebral Microstructural Alterations after Radiation Therapy in High-Grade Glioma: A Diffusion Tensor Imaging-Based Study

by Rebecca Kassubek, Martin Gorges, Mike-Andrew Westhoff, Albert C. Ludolph, Jan Kassubek, Hans-Peter Müller
Published 2017-06-01

Comment in Response to “Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy etc. by B. Kaina”

by Mike-Andrew Westhoff, Tim Baisch, Verena J. Herbener, Georg Karpel-Massler, Klaus-Michael Debatin, Hannah Strobel
Published 2020-04-01

Inhibition of HDAC1/2 Along with TRAP1 Causes Synthetic Lethality in Glioblastoma Model Systems

by Trang T. T. Nguyen, Yiru Zhang, Enyuan Shang, Chang Shu, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Published 2020-07-01

Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems

by Enyuan Shang, Yiru Zhang, Chang Shu, Chiaki Tsuge Ishida, Elena Bianchetti, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Published 2018-10-01

Temozolomide and Other Alkylating Agents in Glioblastoma Therapy

by Hannah Strobel, Tim Baisch, Rahel Fitzel, Katharina Schilberg, Markus D. Siegelin, Georg Karpel-Massler, Klaus-Michael Debatin, Mike-Andrew Westhoff
Published 2019-09-01

Sequential dosing in chemosensitization: targeting the PI3K/Akt/mTOR pathway in neuroblastoma.

by Mike-Andrew Westhoff, Najmeh Faham, Daniela Marx, Lisa Nonnenmacher, Claudia Jennewein, Stefanie Enzenmüller, Patrick Gonzalez, Simone Fulda, Klaus-Michael Debatin
Published 2013-01-01

Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells

by Joachim Bischof, Mike-Andrew Westhoff, Johanna Elisabeth Wagner, Marc-Eric Halatsch, Stephanie Trentmann, Uwe Knippschild, Christian Rainer Wirtz, Timo Burster
Published 2017-03-01

PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma.

by Georg Karpel-Massler, Fresia Pareja, Pascaline Aimé, Chang Shu, Lily Chau, Mike-Andrew Westhoff, Marc-Eric Halatsch, John F Crary, Peter Canoll, Markus D Siegelin
Published 2014-01-01

A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy.

by Stephanie Ströbele, Matthias Schneider, Lukas Schneele, Markus D Siegelin, Lisa Nonnenmacher, Shaoxia Zhou, Georg Karpel-Massler, Mike-Andrew Westhoff, Marc-Eric Halatsch, Klaus-Michael Debatin
Published 2015-01-01

Inhibition of Bcl-2/Bcl-xL and c-MET causes synthetic lethality in model systems of glioblastoma

by Yiru Zhang, Chiaki Tsuge Ishida, Chang Shu, Giulio Kleiner, Maria J. Sanchez-Quintero, Elena Bianchetti, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Published 2018-05-01

Considering the Experimental use of Temozolomide in Glioblastoma Research

by Verena J. Herbener, Timo Burster, Alicia Goreth, Maximilian Pruss, Hélène von Bandemer, Tim Baisch, Rahel Fitzel, Markus D. Siegelin, Georg Karpel-Massler, Klaus-Michael Debatin, Mike-Andrew Westhoff, Hannah Strobel
Published 2020-06-01

Photodynamic Therapy Combined with Bcl-2/Bcl-xL Inhibition Increases the Noxa/Mcl-1 Ratio Independent of Usp9X and Synergistically Enhances Apoptosis in Glioblastoma

by Carolin Golla, Mayas Bilal, Annika Dwucet, Nicolas Bader, Jenson Anthonymuthu, Tim Heiland, Maximilian Pruss, Mike-Andrew Westhoff, Markus David Siegelin, Felix Capanni, Christian Rainer Wirtz, Richard Eric Kast, Marc-Eric Halatsch, Georg Karpel-Massler
Published 2021-08-01

Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl‐xL inhibition

by Trang Thi Thu Nguyen, Chiaki Tsuge Ishida, Enyuan Shang, Chang Shu, Consuelo Torrini, Yiru Zhang, Elena Bianchetti, Maria J Sanchez‐Quintero, Giulio Kleiner, Catarina M Quinzii, Mike‐Andrew Westhoff, Georg Karpel‐Massler, Peter Canoll, Markus D Siegelin
Published 2019-10-01

Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide

by Anna-Laura Potthoff, Dieter Henrik Heiland, Bernd O. Evert, Filipe Rodrigues Almeida, Simon P. Behringer, Andreas Dolf, Ági Güresir, Erdem Güresir, Kevin Joseph, Torsten Pietsch, Patrick Schuss, Ulrich Herrlinger, Mike-Andrew Westhoff, Hartmut Vatter, Andreas Waha, Matthias Schneider
Published 2019-06-01

Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma

by Trang T. T. Nguyen, Enyuan Shang, Chang Shu, Sungsoo Kim, Angeliki Mela, Nelson Humala, Aayushi Mahajan, Hee Won Yang, Hasan Orhan Akman, Catarina M. Quinzii, Guoan Zhang, Mike-Andrew Westhoff, Georg Karpel-Massler, Jeffrey N. Bruce, Peter Canoll, Markus D. Siegelin
Published 2021-09-01

Inhibition of Intercellular Cytosolic Traffic via Gap Junctions Reinforces Lomustine-Induced Toxicity in Glioblastoma Independent of MGMT Promoter Methylation Status

by Matthias Schneider, Anna-Laura Potthoff, Bernd O. Evert, Marius Dicks, Denise Ehrentraut, Andreas Dolf, Elena N. C. Schmidt, Niklas Schäfer, Valeri Borger, Torsten Pietsch, Mike-Andrew Westhoff, Erdem Güresir, Andreas Waha, Hartmut Vatter, Dieter H. Heiland, Patrick Schuss, Ulrich Herrlinger
Published 2021-02-01