Disease Modification in Multiple Sclerosis by Flupirtine—Results of a Randomized Placebo Controlled Phase II Trial

by Jan Dörr, Klaus-Dieter Wernecke, Jens Würfel, Jens Würfel, Judith Bellmann-Strobl, Judith Bellmann-Strobl, Volker Siffrin, Muriel B. Sättler, Mikael Simons, Mikael Simons, Mikael Simons, Andreas Linsa, Andreas Linsa, Hayrettin Tumani, Hayrettin Tumani, Friedemann Paul, Friedemann Paul, Friedemann Paul
Published 2018-10-01

Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution

by Georg Kislinger, Helmut Gnägi, Martin Kerschensteiner, Mikael Simons, Thomas Misgeld, Martina Schifferer
Published 2020-07-01

ATUM-FIB microscopy for targeting and multiscale imaging of rare events in mouse cortex

by Georg Kislinger, Helmut Gnägi, Martin Kerschensteiner, Mikael Simons, Thomas Misgeld, Martina Schifferer
Published 2020-12-01

Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons

by Anja Schneider, Walter Schulz-Schaeffer, Tobias Hartmann, Jörg B. Schulz, Mikael Simons
Published 2006-09-01

Cell visco-elasticity measured with AFM and optical trapping at sub-micrometer deformations.

by Schanila Nawaz, Paula Sánchez, Kai Bodensiek, Sai Li, Mikael Simons, Iwan A T Schaap
Published 2012-01-01

Targeted ablation of oligodendrocytes triggers axonal damage.

by Aniket Ghosh, Natalia Manrique-Hoyos, Aaron Voigt, Jörg B Schulz, Mario Kreutzfeldt, Doron Merkler, Mikael Simons
Published 2011-01-01

Dynamics of the Peripheral Membrane Protein P2 from Human Myelin Measured by Neutron Scattering--A Comparison between Wild-Type Protein and a Hinge Mutant.

by Saara Laulumaa, Tuomo Nieminen, Mari Lehtimäki, Shweta Aggarwal, Mikael Simons, Michael M Koza, Ilpo Vattulainen, Petri Kursula, Francesca Natali
Published 2015-01-01

Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing

by Lu Liu, Simon Besson-Girard, Hao Ji, Katrin Gehring, Buket Bulut, Tuğberk Kaya, Fumere Usifo, Mikael Simons, Ozgun Gokce
Published 2021-06-01

In vivo identification of apoptotic and extracellular vesicle-bound live cells using image-based deep learning

by Jan Kranich, Nikolaos-Kosmas Chlis, Lisa Rausch, Ashretha Latha, Martina Schifferer, Tilman Kurz, Agnieszka Foltyn-Arfa Kia, Mikael Simons, Fabian J. Theis, Thomas Brocker
Published 2020-01-01

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

by Nicolas Snaidero, Caroline Velte, Matti Myllykoski, Arne Raasakka, Alexander Ignatev, Hauke B. Werner, Michelle S. Erwig, Wiebke Möbius, Petri Kursula, Klaus-Armin Nave, Mikael Simons
Published 2017-01-01

Dual-Phase β-Amyloid PET Captures Neuronal Injury and Amyloidosis in Corticobasal Syndrome

by Julia Schmitt, Carla Palleis, Julia Sauerbeck, Marcus Unterrainer, Stefanie Harris, Catharina Prix, Endy Weidinger, Sabrina Katzdobler, Olivia Wagemann, Adrian Danek, Leonie Beyer, Boris-Stephan Rauchmann, Boris-Stephan Rauchmann, Axel Rominger, Axel Rominger, Axel Rominger, Mikael Simons, Mikael Simons, Mikael Simons, Peter Bartenstein, Peter Bartenstein, Robert Perneczky, Robert Perneczky, Robert Perneczky, Robert Perneczky, Christian Haass, Christian Haass, Christian Haass, Johannes Levin, Johannes Levin, Johannes Levin, Günter U. Höglinger, Günter U. Höglinger, Günter U. Höglinger, Matthias Brendel, Matthias Brendel, the German Imaging Initiative for Tauopathies (GII4T)
Published 2021-05-01

A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons.

by Aniket Ghosh, Tina Kling, Nicolas Snaidero, Julio L Sampaio, Andrej Shevchenko, Heribert Gras, Bart Geurten, Martin C Göpfert, Jörg B Schulz, Aaron Voigt, Mikael Simons
Published 2013-01-01

Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork.

by Shweta Aggarwal, Nicolas Snaidero, Gesa Pähler, Steffen Frey, Paula Sánchez, Markus Zweckstetter, Andreas Janshoff, Anja Schneider, Marie-Theres Weil, Iwan A T Schaap, Dirk Görlich, Mikael Simons
Published 2013-01-01

Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS

by Minou Djannatian, Sebastian Timmler, Martina Arends, Manja Luckner, Marie-Theres Weil, Ioannis Alexopoulos, Nicolas Snaidero, Bettina Schmid, Thomas Misgeld, Wiebke Möbius, Martina Schifferer, Elior Peles, Mikael Simons
Published 2019-10-01

Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila.

by Hannes VoSSfeldt, Malte Butzlaff, Katja PrüSSing, Róisín-Ana Ní Chárthaigh, Peter Karsten, Anne Lankes, Sabine Hamm, Mikael Simons, Boris Adryan, Jörg B Schulz, Aaron Voigt
Published 2012-01-01

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

by Marie-Theres Weil, Wiebke Möbius, Anne Winkler, Torben Ruhwedel, Claudia Wrzos, Elisa Romanelli, Jeffrey L. Bennett, Lukas Enz, Norbert Goebels, Klaus-Armin Nave, Martin Kerschensteiner, Nicole Schaeren-Wiemers, Christine Stadelmann, Mikael Simons
Published 2016-07-01

Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication.

by Carsten Frühbeis, Dominik Fröhlich, Wen Ping Kuo, Jesa Amphornrat, Sebastian Thilemann, Aiman S Saab, Frank Kirchhoff, Wiebke Möbius, Sandra Goebbels, Klaus-Armin Nave, Anja Schneider, Mikael Simons, Matthias Klugmann, Jacqueline Trotter, Eva-Maria Krämer-Albers
Published 2013-07-01

A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production

by Vinod Udayar, Virginie Buggia-Prévot, Rita L. Guerreiro, Gabriele Siegel, Naresh Rambabu, Amanda L. Soohoo, Moorthi Ponnusamy, Barbara Siegenthaler, Jitin Bali, AESG, Mikael Simons, Jonas Ries, Manojkumar A. Puthenveedu, John Hardy, Gopal Thinakaran, Lawrence Rajendran
Published 2013-12-01

Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease

by Jakob M Bader, Philipp E Geyer, Johannes B Müller, Maximilian T Strauss, Manja Koch, Frank Leypoldt, Peter Koertvelyessy, Daniel Bittner, Carola G Schipke, Enise I Incesoy, Oliver Peters, Nikolaus Deigendesch, Mikael Simons, Majken K Jensen, Henrik Zetterberg, Matthias Mann
Published 2020-06-01

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

by Alessio Colombo, Lina Dinkel, Stephan A. Müller, Laura Sebastian Monasor, Martina Schifferer, Ludovico Cantuti-Castelvetri, Jasmin König, Lea Vidatic, Tatiana Bremova-Ertl, Andrew P. Lieberman, Silva Hecimovic, Mikael Simons, Stefan F. Lichtenthaler, Michael Strupp, Susanne A. Schneider, Sabina Tahirovic
Published 2021-02-01