Validation of machine learning models to detect amyloid pathologies across institutions

by Juan C. Vizcarra, Marla Gearing, Michael J. Keiser, Jonathan D. Glass, Brittany N. Dugger, David A. Gutman
Published 2020-04-01

Interpretable classification of Alzheimer’s disease pathologies with a convolutional neural network pipeline

by Ziqi Tang, Kangway V. Chuang, Charles DeCarli, Lee-Way Jin, Laurel Beckett, Michael J. Keiser, Brittany N. Dugger
Published 2019-05-01

A mapping of drug space from the viewpoint of small molecule metabolism.

by James Corey Adams, Michael J Keiser, Li Basuino, Henry F Chambers, Deok-Sun Lee, Olaf G Wiest, Patricia C Babbitt
Published 2009-08-01

In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.

by George A Lemieux, Michael J Keiser, Maria F Sassano, Christian Laggner, Fahima Mayer, Roland J Bainton, Zena Werb, Bryan L Roth, Brian K Shoichet, Kaveh Ashrafi
Published 2013-11-01

Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior

by Samantha J. Hindle, Roeben N. Munji, Elena Dolghih, Garrett Gaskins, Souvinh Orng, Hiroshi Ishimoto, Allison Soung, Michael DeSalvo, Toshihiro Kitamoto, Michael J. Keiser, Matthew P. Jacobson, Richard Daneman, Roland J. Bainton
Published 2017-10-01

Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation

by Matthew N. McCarroll, Leo Gendelev, Reid Kinser, Jack Taylor, Giancarlo Bruni, Douglas Myers-Turnbull, Cole Helsell, Amanda Carbajal, Capria Rinaldi, Hye Jin Kang, Jung Ho Gong, Jason K. Sello, Susumu Tomita, Randall T. Peterson, Michael J. Keiser, David Kokel
Published 2019-09-01

Stress testing reveals gaps in clinic readiness of image-based diagnostic artificial intelligence models

by Albert T. Young, Kristen Fernandez, Jacob Pfau, Rasika Reddy, Nhat Anh Cao, Max Y. von Franque, Arjun Johal, Benjamin V. Wu, Rachel R. Wu, Jennifer Y. Chen, Raj P. Fadadu, Juan A. Vasquez, Andrew Tam, Michael J. Keiser, Maria L. Wei
Published 2021-01-01