SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands.

by Sylwia Huber, Fabio Casagrande, Melanie N Hug, Lisha Wang, Philipp Heine, Lutz Kummer, Andreas Plückthun, Michael Hennig
Published 2017-01-01

Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans.

by Jean-Pierre Dangy, Nicole Scherr, Philipp Gersbach, Melanie N Hug, Raphael Bieri, Claudio Bomio, Jun Li, Sylwia Huber, Karl-Heinz Altmann, Gerd Pluschke
Published 2016-06-01

Synthetic single domain antibodies for the conformational trapping of membrane proteins

by Iwan Zimmermann, Pascal Egloff, Cedric AJ Hutter, Fabian M Arnold, Peter Stohler, Nicolas Bocquet, Melanie N Hug, Sylwia Huber, Martin Siegrist, Lisa Hetemann, Jennifer Gera, Samira Gmür, Peter Spies, Daniel Gygax, Eric R Geertsma, Roger JP Dawson, Markus A Seeger
Published 2018-05-01

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

by Manaswini Sivaramakrishnan, Kathleen D. McCarthy, Sébastien Campagne, Sylwia Huber, Sonja Meier, Angélique Augustin, Tobias Heckel, Hélène Meistermann, Melanie N. Hug, Pascale Birrer, Ahmed Moursy, Sarah Khawaja, Roland Schmucki, Nikos Berntenis, Nicolas Giroud, Sabrina Golling, Manuel Tzouros, Balazs Banfai, Gonzalo Duran-Pacheco, Jens Lamerz, Ying Hsiu Liu, Thomas Luebbers, Hasane Ratni, Martin Ebeling, Antoine Cléry, Sergey Paushkin, Adrian R. Krainer, Frédéric H.-T. Allain, Friedrich Metzger
Published 2017-11-01