High Dose Ascorbate Causes Both Genotoxic and Metabolic Stress in Glioma Cells

by Maria Leticia Castro, Georgia M. Carson, Melanie J. McConnell, Patries M. Herst
Published 2017-07-01

Pharmacological doses of daily ascorbate protect tumours from radiation damage after a single dose of radiation in an intracranial mouse glioma model

by Carole eGrasso, Marie-Sophie eFabre, Sarah V Collis, M Leticia Castro, Cameron S Field, Nanette eSchleich, Nanette eSchleich, Melanie J McConnell, Melanie J McConnell, Patries M Herst, Patries M Herst
Published 2014-12-01

Perfluorocarbon emulsions radiosensitise brain tumors in carbogen breathing mice with orthotopic GL261 gliomas.

by Lisa A Feldman, Marie-Sophie Fabre, Carole Grasso, Dana Reid, William C Broaddus, Gregory M Lanza, Bruce D Spiess, Joel R Garbow, Melanie J McConnell, Patries M Herst
Published 2017-01-01

The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy.

by Marie-Sophie Fabre, Nicole M Stanton, Tania L Slatter, Samuel Lee, Dinindu Senanayake, Rosemary M A Gordon, M Leticia Castro, Matthew R Rowe, Ahmad Taha, Janice A Royds, Noelyn Hung, Ari M Melnick, Melanie J McConnell
Published 2020-01-01