Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes

by Christian Setz, Melanie Friedrich, Pia Rauch, Kirsten Fraedrich, Alina Matthaei, Maximilian Traxdorf, Ulrich Schubert
Published 2017-08-01

Just one position-independent lysine residue can direct MelanA into proteasomal degradation following N-terminal fusion of ubiquitin.

by Christian Setz, Melanie Friedrich, Sabine Hahn, Jan Dörrie, Niels Schaft, Gerold Schuler, Ulrich Schubert
Published 2013-01-01

Glutamic Acid Residues in HIV-1 p6 Regulate Virus Budding and Membrane Association of Gag

by Melanie Friedrich, Christian Setz, Friedrich Hahn, Alina Matthaei, Kirsten Fraedrich, Pia Rauch, Petra Henklein, Maximilian Traxdorf, Torgils Fossen, Ulrich Schubert
Published 2016-04-01

Mutation of the Highly Conserved Ser-40 of the HIV-1 p6 Gag Protein to Phe Causes the Formation of a Hydrophobic Patch, Enhances Membrane Association, and Polyubiquitination of Ga...

by Friedrich Hahn, Christian Setz, Melanie Friedrich, Pia Rauch, Sara Marie Solbak, Nils Åge Frøystein, Petra Henklein, Jörg Votteler, Torgils Fossen, Ulrich Schubert
Published 2014-10-01

Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner.

by Friedrich Hahn, Adrian Schmalen, Christian Setz, Melanie Friedrich, Stefan Schlößer, Julia Kölle, Robert Spranger, Pia Rauch, Kirsten Fraedrich, Tatjana Reif, Julia Karius-Fischer, Ashok Balasubramanyam, Petra Henklein, Torgils Fossen, Ulrich Schubert
Published 2017-01-01